187例HIV/AIDS患者机会性感染特点分析
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国家自然科学基金(81001288);江苏省高校自然科学基金(09KTB330004);江苏省卫生科研项目(Y201004)


An analysis of opportunistic infections in 187 HIV/AIDS patients
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    目的:分析南京市艾滋病患者机会性感染 (opportunistic infections,OIs) 特点以及感染发生频率与CD4+ T淋巴细胞计数之间的关系-方法:对南京市第二医院感染科2004~2009年收治的187例住院艾滋病患者的临床资料进行回顾性分析-结果:187例患者中109例 (58.29%) 发生机会性感染,共263例次-入院时基线CD4+ T细胞计数≥ 200个/μl者感染率为9.38% (6/64),计数 < 200个/μl者则为83.74% (103/123),两组比较差异有统计学意义 (χ2 = 95.75,P < 0.05)-多因素Logistic回归分析显示与机会性感染有统计学关联的变量为入院时基线CD4+ T细胞计数 (OR = 0.977,P < 0.001)-随着CD4+ T细胞计数的进行性下降,患者出现临床症状和机会性感染的比例逐步升高-结论:南京市艾滋病患者主要的机会性感染是肺部感染-口腔霉菌感染-卡氏肺孢子菌肺炎-结核病和单纯疱疹病毒感染-在日常治疗中,应定期监测CD4+ T细胞计数,给予预防感染的相关措施,加强治疗随访和数据信息管理-

    Abstract:

    Objective: To analyze the characteristics of opportunistic infections(OIs) in patients with HIV/AIDS in Nanjing and the relationship between the frequency of OIs and the CD4+ T lymphocyte counts. Methods: The characteristics of 187 hospital patients with HIV/AIDS were retrospectively analyzed. These patients were admitted into the Department of Infectious Disease of the Second Hospital of Nanjing from 2004 to 2009. Results: Among 187 patients,109 (58.29%) had OIs,with 263 episodes totally. The prevalence in patients with baseline CD4+ cell counts ≥200 cells /μl(9.38%,6/64) was significantly lower than that in patients with CD4+ cell < 200 cells/μl (83.74%,103/123) (χ2 = 95.75,P < 0.05). The multivariate Logistic analysis showed that the baseline CD4+ counts of patients were significantly related to OIs(OR = 0.977,P < 0.001). With the CD4+ counts continuous were declining,the proportion of clinical symptoms and OIs of patients were gradually rising. Conclusion: The most common OIs in patients with HIV/AIDS were respiratory infections,oral candidacies,Pneumocystis carinii pneumonia(PCP),tuberculosis and viral herpes. In the course of daily treatment,the CD4+ cell counts should be periodically detected,relevant prevention measures of infections should be given,and follow-up and information management should be strengthened.

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雷 娜,姚文虎,魏洪霞,陈 鑫,彭志行,喻荣彬.187例HIV/AIDS患者机会性感染特点分析[J].南京医科大学学报(自然科学版),2011,(9):1379-1382

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  • 收稿日期:2011-04-06
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