256层螺旋CT全脑灌注成像的初步研究
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无锡市医院管理中心科技发展基金资助项目(YGM1015)


Initial experience of whole-brain perfusion imaging performed with 256-slice CT
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    目的:初步评价256层螺旋CT全脑灌注成像对正常脑血流动力学测定的可行性和价值-方法:从拟诊缺血性脑病行头颅平扫-头颅灌注成像及头颈部血管成像的114例患者中选取检查结果正常者35例,记录头颅灌注成像的辐射剂量,由两名高年资神经放射科医生分别对灌注图像进行分析,选择基底节层面和侧脑室体部层面的两侧大脑中动脉供血区的颞叶皮质进行测定,通过手动勾画选定层面的感兴趣区,CT灌注软件自动生成感兴趣区的脑血流量(CBF)-脑血容量(CBV)-平均通过时间(MTT)-达峰时间(TTP)值,测得的灌注参数均值进行单因素方差分析-结果:35例正常人的辐射剂量为(2.307 ± 0.008)mSv-2名分析者所测得侧脑室体部层面和基底节层面的颞叶灰质的CBF-CBV-MTT-TTP值之间无明显统计学差异(P > 0.05)-2名分析者测得的两个层面的颞叶灰质的CBV-CBF值之间均有统计学差异(P < 0.05)-结论:256层螺旋CT全脑灌注成像辐射剂量低,脑灌注参数稳定,能够更真实的反应全脑血流动力学改变-

    Abstract:

    Objective:To preliminarily evaluate the feasibility and potential values of whole-brain perfusion imaging performed with 256-slice CT to assess normal adult cerebral hemodynamics. Methods: Thirty-five normal results were selected from one hundred and fourteen patients who underwent brain CT unenhanced scan,CT perfusion imaging and CT angiography in head and neck for suspicion of ischemic cerebrovascular disease. The radiation dosage of CT perfusion imaging was recorded. Two senior neuroradiologic doctors independently analyzed the CT perfusion maps. Region of interest(ROI) was placed on bilateral temporal gray matter of two slices(the basal ganglia slice and body of lateral cerebral ventricle slice) supplied by middle cerebral artery,and the cerebral blood flow(CBF),cerebral blood volume(CBV),mean transiting time(MTT) and time to peak(TTP) values of ROI were automatically calculated by CT perfusion software. The mean values of perfusion parameters were compared by one-way ANOVA test. Results: The radiation dosage of thirty-five normal adults was 2.307 ± 0.008 mSv. There were no statistically significant differences between the two observers on the mean values of perfusion parameters(P > 0.05). The CBV and CBF values of the two observers between two slices had statistically differences(P < 0.05). Conclusion: With the lower radiation dosage and the stable and reproducible perfusion parameters,whole-brain perfusion imaging performed with 256-slice CT can be used to assess the entire cerebral hemodynamics.

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唐 健,姜建威,常 军,侯海燕,姜旭栋,堵红群.256层螺旋CT全脑灌注成像的初步研究[J].南京医科大学学报(自然科学版),2011,(10):1510-1512

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  • 收稿日期:2011-04-15
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