输卵管组织LIF及其受体LIFR的表达与输卵管妊娠的关系
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江苏省自然科学基金(BK2010583),常州市科技局科研基金资助(CS20092013)


The correlation between the occurrence of tubal pregnancy and the expression levels of LIF and LIFR in oviduct tissues
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    目的:探讨白血病抑制因子(LIF)及其受体(LIFR)与输卵管异位妊娠的关系-方法:采用免疫组化技术检测11例非孕组和36例输卵管异位妊娠组输卵管组织中LIF和LIFR的表达水平,半定量分析其在各组间的表达差异-结果:无论是在输卵管腺上皮还是间质中,LIF在非孕组和异位妊娠组间的表达无明显差别;但是在输卵管腺上皮中,LIFR的表达异位妊娠组高于非孕组(P < 0.05);而在间质中,LIFR的表达输卵管妊娠组明显低于非孕组(P < 0.01)-结论:LIFR的异常表达可能与输卵管异位妊娠的发生密切相关-

    Abstract:

    Objective: To explore the correlation between the occurrence of tubal pregnancy and the expression level of leukemia inhibitory factor (LIF) and LIF receptor (LIFR). Methods: Semi-quantitative analysis of LIF and LIFR by immunohistochemistry was performed in 11 fallopian tubal tissues of non-pregnant group,and 36 of tubal pregnancy group,respectively. Results: The LIFR expression level in fallopian tubal epithelium cells of tubal pregnancy group was significantly higher than that of non-pregnant group. While the LIFR abundance in interstitial cells of tubal pregnancy group was significantly lower than that of non-pregnant group. However,no significant difference of LIF abundance was found between two groups. Conclusion: Aberrant expression of LIFR in oviduct tissues might be involved in the ectopic implantation process of tubal pregnancy.

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李 咏,孙丽洲,赵丹梅,欧阳俊,向 梅,马文琴,吴超英,史文忠,唐正华.输卵管组织LIF及其受体LIFR的表达与输卵管妊娠的关系[J].南京医科大学学报(自然科学版),2011,(11):1663-1666

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  • 收稿日期:2011-07-26
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