Objective: To evaluate the association between coronary heart disease(CHD) and serum concentration of monocyte chemoattractant protein-1(MCP-1). Methods: CNKI,WanFang,VIP and PubMed databases were searched,and the end time was December 31,2010. Statistical analysis was performed with the software program review manage,version 4.2. Fixed-effects model and random-effects model were applied to process these data. Results: There were 13 clinical trials qualified under our selection criteria. The study included 396 stable angina(SA) patients,366 unstable angina(UA) patients,268 acute myocardial infarction(AMI) patients and 446 healthy control group. Meta-analysis showed that the standardized mean difference(SMD)of MCP-1 concentrations in the patients with SA was 0.71(95%CI:0.30~1.12),SMD of UA group was 1.98(95%CI:1.15~2.81),SMD of AMI group was 2.69(95%CI:1.67~3.70). Each SMD of those three groups was higher than that of the healthy control group(P < 0.01). Moreover,serum MCP-1 concentrations in the patients with UA were 0.77 to 2.20 times of standard deviation higher than those in the patients with SA,and the concentrations of serum MCP-1 in the patients with AMI were 0.32 to 0.67 times of standard deviation higher compared to those in the patients with UA. Conclusion: High serum MCP-1 level is associated with the severity of CHD,while the precise relationship between serum MCP-1 concentration and CHD in Chinese population requires prospective study.