Objective:To study the expression differences of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) protein in extramammary Paget disease (EMPD) tissues and corresponding adjacent normal skin and mucosa tissues,and explore their relationship in angiogenesis of EMPD tissue. Methods:We detected VEGF and bFGF protein expression by immunohistochemical staining in EMPD tissue and corresponding adjacent normal skin and mucosa from nine cases and combined their clinical data to perform statistical analysis. Results:We found that VEGF and bFGF protein staining signals(score) in EMPD tissues were significantly stronger than that of the adjacent normal skin and mucosa (P < 0.05). Furthermore,we found that “signal rate ratio” of the two proteins(bFGF/VEGF) was significantly higher in EMPD tissues than that of adjacent normal mucosa (t = 2.630,P = 0.030). Conclusion:VEGF and bFGF gene products are key signaling proteins in EMPD angiogenesis,and the interaction of the two stimulus signals plays a facilitating role in the occurrence and development of EMPD,especially the high expression of bFGF. How to block the over-expression of VEGF and bFGF in EMPD to destroy the blood supply of tumor cells and restrain the rapid occurrence and development of tumor is still the next focus of our study.