人端粒酶逆转录酶在良性前列腺增生?前列腺上皮内瘤及前列腺癌中的表达及其意义
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国家自然科学基金(30860284);贵州省优秀科技教育人才省长专项资金[黔省专合字2007(76)号]


Expression of human telomerase reverse transcriptase in benign prostatic hyperplasia,prostatic intraepithelial neoplasia and prostate carcinoma
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    摘要:

    目的:探讨人端粒酶逆转录酶在良性前列腺增生-前列腺上皮内瘤及前列腺癌组织中的原位表达及其意义-方法:收集良性前列腺增生15例-前列腺上皮内瘤11例及前列腺癌17例-应用免疫组织化学法检测组织中人端粒酶逆转录酶的原位表达,分析良性前列腺增生-前列腺上皮内瘤及前列腺癌中的表达差异并探讨Gleason评分与人端粒酶逆转录酶表达强度的相关性-统计学分析采用Fisher确切概率法和Spearman秩相关分析-结果:人端粒酶逆转录酶的阳性表达率差异在良性前列腺增生组与前列腺癌组间有统计学意义(0% vs 88.24%,P < 0.001);在前列腺上皮内瘤组与前列腺癌组间有统计学意义(36.36% vs 88.24%,P = 0.01);在前列腺上皮内瘤组与良性前列腺增生组间也有统计学意义(36.36% vs 0%,P = 0.022)-Gleason评分与人端粒酶逆转录酶表达强度呈正相关(P < 0.05)-结论:人端粒酶逆转录酶在前列腺组织中的高表达,对于鉴别病变的良恶性具有重要意义;人端粒酶逆转录酶在前列腺癌中的表达强度随着Gleason评分的增加而呈现增强趋势;而人端粒酶逆转录酶在前列腺上皮内瘤中表达阳性的患者应列为密切的临床监控对象-

    Abstract:

    Objective:To investigate the in situ expression of human telomerase reverse transcriptase (hTERT) in benign prostatic hyperplasia (BPH),prostate intraepithelial neoplasia (PIN) and prostate carcinoma (PCa) tissues and its clinic significance. Methods:Using immunohistochemical method,the expression of hTERT was examined in 43 specimens of prostate tissues,including 15 cases of BPH,11 cases of PIN and 17 cases of PCa. The association of Gleason score and expression of hTERT was explored. Data were analyzed by Fisher’s Exact Test and Spearman’s rho analysis. Results:1. The hTERT protein was expressed in 15 out of 17 PCa cases (88.24%),4 out of 11 PIN cases (36.36%),and 0 of 15 cases of BPH . A significant difference of expression was observed in the comparison of each two groups(all P < 0.05). 2. The intensity of hTERT expression in prostate carcinoma increases along with the Gleason score. The intensity of hTERT expression in prostate carcinoma was positively related to the Gleason score(P < 0.05). Conclusion:The hTERT protein is highly expressed in prostate tissue,which may be applied as a biomarker for differential diagnosis between benign and malignant lesions. The intensity of hTERT expression in PCa increases along with the Gleason score. PIN patients with positive expression of hTERT should be closely observed and fellowed up.

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毕 磊,陈方敏,石家齐,严 波,肖 峰,范诗秋.人端粒酶逆转录酶在良性前列腺增生?前列腺上皮内瘤及前列腺癌中的表达及其意义[J].南京医科大学学报(自然科学版),2012,(5):673-676

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  • 收稿日期:2011-10-25
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