Objective:To observe the correlation of single-nucleotide polymorphisms(SNPs) of chitinase 3-like protein 1(CHI3L1)-329 G/A and coronary artery disease(CAD) in Jiangsu province. Methods:Total 391 patients were enrolled,including 189 patients with CAD and 202 controls. The SNP at CHI3L1 -329 G/A was genotyped by ligase detection reaction. Results:Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of A allele and A allele carriers among SAP,UAP,and MI groups(P < 0.05 respectively). No associations existed between the SNP and the severity of coronary artery stenosis(All P > 0.05). Conclusion:These results did not support an involvement of SNP rs10399931 of CHI3L1 -329 G/A in predisposition to CAD in Jiangsu area.