新鲜芦荟对静脉炎治疗效果的实验观察
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河南省卫生厅医学科技攻关计划项目(2010 03084)


An experimental observation on using fresh aloe to treat phlebitis
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    目的:通过病理观察探讨芦荟对静脉炎的治疗效果,寻找静脉炎的治疗方法-方法:选用新西兰大耳白兔30只,双侧耳缘静脉留置针穿刺置管,模拟临床输液,留置5 d致静脉炎后拔出留置针,将兔随机分为模型组-实验Ⅰ组-实验Ⅱ组,每组10只-模型组不做任何处理,分组后即留取标本;实验Ⅰ组用50%硫酸镁湿敷,实验Ⅱ组用新鲜芦荟湿敷-实验组均外加保鲜膜包裹,每次敷4 h,每天2次,治疗5 d后留取标本做切片,HE染色光镜观察血管内膜及周围组织的病理改变,透射电镜观察内皮细胞超微结构变化-结果:3组血管炎症反应程度比较差异有明显统计学意义(P < 0.001);透射电镜观察实验Ⅰ组和实验Ⅱ组血管内皮细胞线粒体和粗面内质网肿胀程度较模型组均减轻,实验Ⅱ组比实验Ⅰ组减轻更显著-结论:新鲜芦荟和50%硫酸镁治疗静脉炎均有效,新鲜芦荟治疗效果优于50%硫酸镁-

    Abstract:

    Objective:To evaluate effect of fresh aloe treating phlebitis and find a way to cure phlebitis. Methods:Thirty healthy large-eared New Zealand rabbits were chozed. Two edged-veins in both ears were set intravenous indwelling needle mimicing real clinic transfusion. The indwelling needles were extracted when phlebitis occurred 5 days after needles setting. Then they were randomly divided into model group,experimental group Ⅰ and experimental group Ⅱ,10 rabbits each. Model group did not give any treatment,and the specimens were taken immediately after group divided. The experimental group Ⅰ were given wet compress with 50% magnesium sulfate. Experimental group Ⅱ were given wet compress with fresh aloe, both groups given extra plastic wrap,4 h each time,2 times per day. After 5 days specimens were taken for pathological observation. Hematoxylin-eosin staining was used to observe pathological changes of vascular intima and beneath connective tissue,transmission electron microscope to observe ultrastructural changes of vascular endothelial cells. Results:There were significant statistical differences in inflammatory effect among three groups (P < 0.001);Transmission electron microscope showed that cytoplasm mitochondria and rough endoplasmic reticulum swelling in experimental group Ⅰ and Ⅱ was less than that in model group. And the swelling in experimental group Ⅱ was less than that in experimental group Ⅰ. Conclusion:Fresh aloe and 50% of magnesium sulfate are both useful to treat phlebitis,but fresh aloe treatment is more effective than 50% magnesium sulfate.

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路雪芹,黄 霞,陈传波,景 红,吴 江.新鲜芦荟对静脉炎治疗效果的实验观察[J].南京医科大学学报(自然科学版),2012,(7):965-968

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  • 收稿日期:2011-11-30
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