Objective:To investigate the safty and feasibility of percutaneous balloon mitral valvuloplasty(PBMV) on women of child-bearing age with severe rheumatic mitral stenosis and the effect of subsequent pregnancy on cardiac function. Methods:PBMV was made in 9 female patients(mean age 24.6 years) admitted in our hospital since January 2000 to December 2011,whose clinical and echo cardiographic evaluation were obtained with a follow-up of 2.5~7.0 years. Results:The procedure was successful in all 9 patients,with no severe complication. There was significant difference in left atrial mean pressure,mitral valve pressure gradient and mitral valve area after the procedure. All patients subsequently got pregnant and had normal vaginal deliveries. The children had normal growth and development with the Apgar score of 9~10. No signifcant change was observed in all echocardiographic parameters and cardiac function before pregnancy and after delivery. Conclusion:In women of child-bearing age with symptomatic mitral stenosis,PBMV is feasible,safe and effective.