乳腺癌组织HER-2/neu 和RECK蛋白的表达及其意义
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南京医科大学附属江苏省肿瘤医院科研基金(ZM200802)


Expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue
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    摘要:

    目的:探讨HER-2/neu和RECK蛋白在乳腺癌组织中的表达及其临床意义-方法:采用SP法,对76例乳腺癌组织标本及30例正常乳腺组织标本进行免疫组化检测,观察乳腺癌组织及正常乳腺组织中HER-2/neu和RECK蛋白表达情况,并比较不同TNM分期-病理分化程度乳腺癌组织HER-2/neu和RECK蛋白表达强度及阳性率差异,分析其两者之间的关系-结果:乳腺癌组织HER-2/neu表达强度及阳性率高于正常乳腺组织,RECK表达强度及阳性率低于正常乳腺组织,乳腺癌组织中HER-2/neu和RECK表达强度及阳性率同TNM分期及肿瘤组织分化具有相关性,乳腺癌组织HER-2/neu和RECK表达呈负相关-结论:乳腺癌组织中HER-2/neu过度表达-RECK表达减弱或缺失的现象,可能是乳腺癌发生-发展的生物学机制之一-

    Abstract:

    Objective:To investigate the expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue. Methods:A total of 76 cases of breast carcinoma tissue and 30 cases of normal breast tissue were selected and stained with SP immunohistochemical method to detect the expression of HER-2/neu and RECK,positive rate and intensity were compared among cases with different TNM stage and differentiation of breast carcinoma,correlation between HER-2/neu and RECK was analyzed in breast carcinoma tissue. Results:Positive rate and intensity of HER-2/neu were higher and RECK were lower in breast carcinoma tissue than those in normal breast tissue,which were correlative with TNM stage and differentiation of breast carcinoma,the expression of HER-2/neu was negatively correlated with RECK in breast carcinoma tissue. Conclusion:HER-2/neu was over expressed while RECK was not expressed or at a low level in breast carcinoma tissue,these might be a biological mechanism for the occurrence and progression of breast carcinoma.

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沈 波,韦 达,徐新宇,陈 嘉,郑马庆.乳腺癌组织HER-2/neu 和RECK蛋白的表达及其意义[J].南京医科大学学报(自然科学版),2012,(9):1237-1240

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  • 收稿日期:2012-05-10
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