不稳定型心绞痛患者C-反应蛋白基因多态性与其血清水平的相关性
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常州市科技计划项目[常科发(2009)90号]


The correlation of CRP gene polymorphism and its serum level in patients with unstable angina pectoris
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    目的:探讨中国苏南地区汉族人群不稳定型心绞痛(unstable angina pectoris,UAP)患者C-反应蛋白(C-reactive protein,CRP)基因+1444C/T多态性与其血清CRP水平的相关性-方法:本研究包括172例不稳定型心绞痛患者(UAP组)和230例非冠心病者(对照组),分别应用酶联免疫吸附法和聚合酶链反应-限制性片段长度多态性法检测血清CRP水平及CRP基因+1444C/T多态性-结果:①本研究人群存在CRP基因+1444C/T多态性;②UAP患者血清CRP水平(8.269/9.179 μg/ml)显著高于非冠心病者(3.578/2.236 μg/ml)(P < 0.001),且经多因素Logistic回归校正各影响因素后,仍提示血清CRP水平与UAP发病风险相关;③血清CRP水平在UAP组与对照组各基因型之间无显著差异(P > 0.05),进一步按性别和年龄分组后,仍未发现该基因多态性不同基因型间的血清CRP水平有任何差异(P > 0.05)-结论:中国苏南地区汉族人群CRP+1444C/T基因多态性与血清CRP水平无相关性-

    Abstract:

    Objective:To investigate the correlation between C-reactive protein(CRP) gene +1444C/T polymorphism with the risk of unstable angina pectoris(UAP) and the serum CRP level in the ethnic Sunan Han population of China. Methods:The serum level of CRP was measured by enzyme-linked immunosorbent assay and the CRP gene +1444C/T polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism between 172 patients with UAP and 230 control subjects. Results:① There was CRP gene +1444C/T polymorphism in this study population;② The serum CRP level in UAP patients (8.269/9.179 μg/ml) was significantly higher than those in control subjects (3.578/2.236 μg/ml)(P < 0.001) and multivariate logistic regression analysis showed that the serum CRP level was a risk factor of UAP;③ There was not difference in the serum CRP level in any genotypes of the CRP gene +1444C/T polymorphism between the UAP group and the control group(P > 0.05) and further grouped by gender and age. Conclusion:There was no relationship between CRP gene +1444C/T polymorphism with its serum level in the ethnic Sunan Han population of China.

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杨海涛,何国平,戚传平,许联红,钱亿超.不稳定型心绞痛患者C-反应蛋白基因多态性与其血清水平的相关性[J].南京医科大学学报(自然科学版),2012,(9):1246-1249

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  • 收稿日期:2012-03-14
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