尿MCP-1、血浆IL-8在紫癜性肾炎诊断中的价值
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南通市社会发展科技计划(S2008047)


The diagnose value of urinary MCP-1 and plasma interleukin-8 in purpura nephritis
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    摘要:

    目的:探讨尿单核细胞趋化蛋白-1(MCP-1)与血浆白细胞介素-8(IL-8)在紫癜性肾炎中的诊断价值-方法:将57例过敏性紫癜患儿纳入实验组,其中合并紫癜性肾炎的45例细胞,按照尿微量白蛋白(UMALB)测定分为正常尿白蛋白组(第1组)-微量尿白蛋白组(第2组)及大量尿白蛋白组(第3组);12例无尿常规异常者为单纯性紫癜组(第4组);同期选取19例健康儿童作为对照组-酶联免疫吸附双抗体夹心法测定尿MCP-1及血浆IL-8水平,并比较各组间尿MCP-1及血浆IL-8水平的差异;计算紫癜性肾炎病例尿MCP-1-血浆IL-8在ROC曲线下面积,分析其在紫癜性肾炎中的诊断价值-结果:尿MCP-1水平在1~4组间比较差异有统计学意义(F = 88.52,P < 0.01),且随着尿白蛋白的增加,尿MCP-1水平随之上升,组间两两比较,差异均有统计学意义(P < 0.01)-血浆IL-8水平在1~4组及对照组组间比较差异有统计学意义(F = 289.55,P < 0.01),两两比较显示:血浆IL-8水平在不同水平尿白蛋白组(1~3组)间比较差异有统计学意义(P < 0.01);而正常尿白蛋白组(第1组)与单纯性紫癜组(第4组)比较差异无统计学意义(P > 0.05);1~4组血浆IL-8水平均显著高于对照组(P < 0.01)-尿MCP-1-血浆IL-8在ROC曲线下面积分别为0.90-0.83,其诊断界值分别为111.50-349.54 ng/L,灵敏度分别达到82.22%-68.89%-结论:尿MCP-1对紫癜性肾炎早期诊断的灵敏度优于血浆IL-8,且两者都有助于判断紫癜性肾炎肾脏损害的轻重程度-

    Abstract:

    Objective:To explore the diagnose value of the urine monocyte chemoattractant protein-1(MCP-1) and plasma interleukin-8(IL-8) in purpura nephritis. Methods:There were 57 cases who suffered from Henoch-Schonlein purpura included in the experimental group,including 45 cases complicated with purpura nephritis. According to the level of urinary albumin,they were divided into 4 groups:group 1(normal urinary albumin),group 2(micro urinary albumin),group 3(a large number of urinary albumin),group 4 (simple purpuric group with normal urine). In the same period,19 cases of healthy children were selected as control group. The urinary MCP-1,and plasma IL-8 were examined in all cases by ELISA. The differences of urinary MCP-1,plasma IL-8 levels were compared among all the group,and the areas under the ROC curves were caculated. Results:The comparative differences of urine MCP-1 level from experimental group 1 to 4 had statistical significance(F = 88.52,P < 0.01). With the increase of urinary albumin,the urine MCP-1 level increased altogether. The differences from comparisons between one group and another all had statistical significance(P < 0.01). The comparative differences of plasma IL-8 levels from experimental group 1 to 4 and the control group had statistical significance (F = 289.55,P < 0.01). Comparisons between one group and another indicate:The comparative differences of plasma IL-8 level in urine albumin groups(group 1 to 3) of different levels had statistical significance(P < 0.01),whereas the comparative difference of normal urinary albumin group(group 1) and simple purpura group(group 4) did not have statistical significance(P > 0.05). The plasma IL-8 level of experimental groups(group 1 to 4) was obviously higher than that of control groups in average(P < 0.01). The areas under ROC curvs of urine MCP-1 and plasma IL-8 were 0.90 and 0.83. Their diagnostic boundary values were 111.50 ng/L and 349.54 ng/L and their sensitivities were 82.22% and 68.89%. Conclusion:The sensitivity of urine MCP-1 to the early diagnosis of Henoch-Schonlein purpura nephritis(HSPN) was superior to that of plasma IL-8. And these two are both helpful for the judgment of the severity of HSPN damage.

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蔡 晋,徐美玉,赵建美,吴尤佳,张向东.尿MCP-1、血浆IL-8在紫癜性肾炎诊断中的价值[J].南京医科大学学报(自然科学版),2012,(9):1272-1276

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  • 收稿日期:2012-05-02
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