Objective:To explore the diagnose value of the urine monocyte chemoattractant protein-1(MCP-1) and plasma interleukin-8(IL-8) in purpura nephritis. Methods:There were 57 cases who suffered from Henoch-Schonlein purpura included in the experimental group,including 45 cases complicated with purpura nephritis. According to the level of urinary albumin,they were divided into 4 groups:group 1(normal urinary albumin),group 2(micro urinary albumin),group 3(a large number of urinary albumin),group 4 (simple purpuric group with normal urine). In the same period,19 cases of healthy children were selected as control group. The urinary MCP-1,and plasma IL-8 were examined in all cases by ELISA. The differences of urinary MCP-1,plasma IL-8 levels were compared among all the group,and the areas under the ROC curves were caculated. Results:The comparative differences of urine MCP-1 level from experimental group 1 to 4 had statistical significance(F = 88.52,P < 0.01). With the increase of urinary albumin,the urine MCP-1 level increased altogether. The differences from comparisons between one group and another all had statistical significance(P < 0.01). The comparative differences of plasma IL-8 levels from experimental group 1 to 4 and the control group had statistical significance (F = 289.55,P < 0.01). Comparisons between one group and another indicate:The comparative differences of plasma IL-8 level in urine albumin groups(group 1 to 3) of different levels had statistical significance(P < 0.01),whereas the comparative difference of normal urinary albumin group(group 1) and simple purpura group(group 4) did not have statistical significance(P > 0.05). The plasma IL-8 level of experimental groups(group 1 to 4) was obviously higher than that of control groups in average(P < 0.01). The areas under ROC curvs of urine MCP-1 and plasma IL-8 were 0.90 and 0.83. Their diagnostic boundary values were 111.50 ng/L and 349.54 ng/L and their sensitivities were 82.22% and 68.89%. Conclusion:The sensitivity of urine MCP-1 to the early diagnosis of Henoch-Schonlein purpura nephritis(HSPN) was superior to that of plasma IL-8. And these two are both helpful for the judgment of the severity of HSPN damage.