猪急性心肌梗死造模中恶性心律失常发生率及与QT?QTc间期的关系
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江苏高校优势学科建设工程项目(Jx10231081)


Malignant arrhythmia in swine model of acute myocardial infarction and its association with QT and QTc interval
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    目的:探讨不同部位封堵左前降支(left anterior descending artery,LAD)对猪急性心肌梗死(acute myocardial infarction,AMI)模型恶性心律失常发生情况及其与QT间期-校正后QT间期(QTc间期)的关系-方法:选择22头苏中幼猪,采用介入法球囊封堵猪LAD建立AMI动物模型-根据LAD封堵造模的部位,将动物随机分为3组,其中假手术对照组(Sham组,不封堵)4只,LAD下1/3处封堵组和LAD中部封堵组各9只,观察各组在造模过程中恶性心律失常(室性心动过速或心室颤动)的发生率,造模成功后记录并分析各组心电参数指标-结果:LAD中部封堵组心室颤动发生率显著高于下1/3处封堵组(100.00% vs 33.33%,P < 0.05)-造模成功后,LAD中部封堵组QT间期同下LAD 1/3处封堵组比较,差异无统计学意义[(362.11 ± 29.18) ms vs(338.78 ± 22.65) ms,P > 0.05];而LAD中部封堵组QTc间期较下LAD 1/3处封堵组延长,差异具有统计学意义[(462.67 ± 27.55) ms vs (425.56 ± 21.96) ms,P < 0.01]-结论:猪急性心肌梗死后恶性心律失常发生与QTc间期延长具有一定的相关性-

    Abstract:

    Objective:To explore the malignant arrhythmia of swine models in plugging left anterior descending artery (LAD) at different segments and its association with QT and QTc interval. Methods:Total 22 swine were chosen to undergo occlusion of coronary artery with balloon angioplasty. The animals were randomly divided into 3 groups according to the occlusion position of balloon:①Sham group:no occlusion of LAD(n = 4);② The occlusion at lower 1/3 segment of LAD group(n = 9); ③ The occlusion at middle segment of LAD group(n = 9). Then the incidence of malignant arrhythmia (ventricular tachycardia or ventricular fibrillation) was observed in the process of molding,and the QT and QTc interval were analyzed after models made successfully. Results:The incidence of ventricular fibrillation in the middle segment of LAD plugging group was significantly higher than the lower 1/3 segment of LAD plugging group (100% vs 33.33%,P < 0.05). After the models constructed,the QT interval between the two groups showed no significant difference [(362.11±29.18) ms vs (338.78 ± 22.65) ms,P > 0.05]. However,the QTc interval was significantly longer in the middle segment of LAD plugging group than in the lower 1/3 segment of LAD plugging group[ (462.67 ± 27.55) ms vs (425.56 ± 21.96)ms,P < 0.01). Conclusion:Malignant arrhythmia after acute myocardial infarction in swine models was associated with prolonged QTc interval.

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陈 彦,王淦楠,黄培培,胡德亮,吕金如,孙 昊,吴鸿浩,乔 莉,张劲松,吴 昊.猪急性心肌梗死造模中恶性心律失常发生率及与QT?QTc间期的关系[J].南京医科大学学报(自然科学版),2012,(11):1533-1536

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  • 收稿日期:2012-09-04
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