Objective:To investigate the mRNA and protein expression differences of vitamin D receptor(VDR) in subcutaneous and omental adipose tissue of people with different BMI. Methods:Twenty people of normal BMI,35 people of overweight and 27 people of obesity were selected. The mRNA transcription levels of VDR were assayed by RT-PCR,and the VDR protein expression was measured by Western blot. Results:① In subcutaneous obesity tissue,mRNA transcription and protein expression of VDR was lower in obesity group than in the normal or overweight group(P < 0.05);② In omental adipose tissue,mRNA transcription and protein expression of VDR was highest in overweight group among 3 groups(P < 0.05). Compared with the overweight group,mRNA transcription and protein expression of VDR was lower in obesity group(P < 0.05). Conclusion:The VDR expression decreased in the obesity group,which may be one of the mechanisms of the poor clinical outcome of vitamin D intervention therapy.