Objective:To investigate the association of I198T and R92H point mutations in lipoprotein-associated phospholipaseA2 (Lp-PLA2)with coronary heart disease(CHD) in the Chinese Han population. Methods:Totally 173 CHD patients and 101 normal controls were genotyped by DNA sequencing instrument. Results:There was no significant difference between the CHD group and the control group in the frequencies of I198T genotypes and allele,but the frequencies of the R92H genotypes and allele were significantly higher in CHD patients than those in normal controls (P < 0.05). The levels of total cholesterol (TC)and low density lipoprotein cholesterol (LDL-C)were significantly higher in the RH+HH genotype group than in the RR genotype group (P < 0.01). The distributions of haplotype IH and IR had a significant difference (P < 0.01)between CHD patients and normal controls. Binary logistic regression analysis demonstrated that polymorphism of R92H was an independent risk factor for CHD. Conclusion:The I198T polymorphism of Lp-PLA2 gene has no significant correlation with coronary heart disease,while the polymorphism of R92H could be associated with risk of CHD in Chinese Han population.