Objective:The purpose of this study is to analyze and discuss the efficiency of real-time tissue elastography (RTE) in diagnosis of liver fibrosis. Methods:RTE was performed on 41 patients with chronic hepatitis B to measure the stage of liver fibrosis,from which a quantitative parameter-liver fibrosis index (LF index) was obtained. Simultaneously,biochemical test and liver biopsy were performed in all patients. We compared the results among different stages of S1,S2,S3 and S4 liver fibrosis reported by biopsy considered as the gold standard for the assessment of liver fibrosis. Results:Significantly different were found in LF index,APRI and FIB-4 of liver fibrosis groups(P﹤0.05). LF index,APRI and FIB-4 increased as the stage of liver fibrosis(P < 0.001). LF index correlated positively with APRI,FIB-4,respectively (P﹤0.01). Taking S4 as the diagnosis standard of early liver cirrhosis,the area under the curve of ROC for LF index,APRI and FIB-4 was 0.934(P < 0.001),0.851(P < 0.001),0.899(P < 0.001),respectively. Conclusion:RTE with potential practical value in the clinical has certain diagnostic efficiency in evaluating the stage of liver fibrosis.