苏州儿童重症监护病房呼吸机相关性肺炎肺炎克雷伯杆菌耐药分析
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苏州市科技项目(SYS201140)


Analysis of drug resistance of Klebsiella pneumonia in ventilator associated pneumonia in pediatric intensive care unit in Suzhou
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    摘要:

    目的:调查苏州儿童重症监护病房(pediatric intensive care unit,PICU)呼吸机相关性肺炎肺炎克雷伯杆菌耐药特征,为预防和临床治疗提供依据。方法:选取苏州大学附属儿童医院2011年8月~2012年1月入住PICU患儿中,符合呼吸机相关性肺炎(ventilator -associated pneumonia,VAP)诊断标准,且气管插管内痰标本培养为肺炎克雷伯杆菌的标本进行药敏试验分析。根据是否产超广谱β-内酰胺酶(extended-spectrum β-lactamases,ESBLs)分为ESBLs阳性组和ESBLs阴性组,分别比较两组菌株对抗生素的耐药性差异。结果:共收集39份下气道肺炎克雷伯杆菌痰标本(来自31例患儿),39份肺炎克雷伯杆菌培养阳性菌株均进行药敏试验,所有菌株均对氨苄西林耐药,对头孢他啶耐药菌株32例,耐药率达82.05%(32/39),其余常见抗生素的耐药从高到低依次为头孢呋辛脂(89.74%,35/39),头孢吡肟(76.92%,30/39),头孢噻肟(76.92%,30/39)。对头孢西丁耐药率较低(17.95%,7/39),所有菌株均对亚胺培南敏感。ESBLs阳性组对第2-3-4代头孢菌素的耐药率高于ESBLs阴性组菌株(P < 0.05)。结论:苏州地区PICU中VAP肺炎克雷伯杆菌感染以ESBLS阳性菌株为常见。与ESBLs阴性菌株比较,其对第2-3-4头孢菌素耐药率明显增高。碳青酶烯类抗生素是治疗VAP肺炎克雷伯菌感染的首选药物,临床应根据肺炎克雷伯杆菌的耐药性分析合理使用抗生素。

    Abstract:

    Objective:To investigate the drug resistance of Klebsiella pneumonia in ventilator associated pneumonia in pediatric intensive care unit (PICU) in Suzhou,and provide the basis of prevention and clinical treatment. Methods:Children recruited in PICU from Aug. 2011 to Jan. 2012 who met the diagnostic criteria of ventilator associated pneumonia(VAP) and sputum culture showed Klebsiella pneumonia positive were studied. According to extended-spectrum β-lactamases(ESBLs),they were divided into two groups:ESBLs positive and ESBLs negative. The difference of drug resistance was analyzed. Results:Totally 39 sputum specimens from 31 children were collected and under susceptibility test. All strains showed ampicillin resistance,32 strains showed eftazidime resistance,the drug resistance rate was increased to 82.05% (32/39). Other antibiotics resistances were cefuroxime axetil (89.74%,35/39),cefepime (76.92%,30/39) and cefotaxim (76.92%,30/39). Cefoxitin had a lower resistance (17.95,7/39). All strains were sensitive to imipenem. The drug resistance(of the 2nd,3rd and 4th generation of cephalosporin) rate in the ESBLs positive group was higher than that in the ESBLs negative group(P < 0.05). Conclusion:ESBLs positive strains are more common in VAP Klebsiella pneumonia infection in PICU in Suzhou,and have a higher cephalosporin resistance compared to the ESBLS negative strains. Carbapenem is the first choice drug to treat VAP Klebsiella pneumonia infection. Doctors should choose suitable antibiotics according to the resistance.

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项 龙,李 莺,柏振江,陶云珍,丁云芳,谢敏慧.苏州儿童重症监护病房呼吸机相关性肺炎肺炎克雷伯杆菌耐药分析[J].南京医科大学学报(自然科学版),2013,(4):502-505

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  • 收稿日期:2012-10-09
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  • 在线发布日期: 2013-04-29
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