射频超声技术评价糖耐量减低患者颈动脉弹性的临床研究
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江苏省科技支撑计划——社会发展资助(SBE 200970427)


Evaluation of carotid artery elasticity in patients with impaired glucose tolerance by ultrasound radio-frequency data technique
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    摘要:

    目的:探讨射频超声技术在糖耐量减低患者颈动脉弹性中的临床应用价值。方法:选取58例糖耐量减低的人群和39例健康者作为研究对象。利用射频超声技术对颈总动脉行超声检查,记录颈动脉弹性参数,包括血管内中膜厚度(IMT) -动脉管壁的扩张度(e)-顺应性系数(CC) -僵硬度系数(β) -脉搏波传导速度(PWV),运用统计学方法比较各参数的差异并对其进行相关性分析。结果:①与正常对照组相比,IGT组的体质指数(BMI)-餐后2 h血糖(2-hPG)-总胆固醇(TC)-甘油三酯(TG)明显高于对照组,差异有统计学意义(P < 0.05);②IGT组的IMT--茁-PWV均明显增高,颈动脉弹性系数e-CC均明显降低(P < 0.05),差异有统计学意义;③应用Pearson相关分析发现病例组颈动脉IMT与PWV-年龄--茁呈正相关(r = 0.290~0.661,P均< 0.05);PWV与年龄-IMT--茁呈正相关(r = 0.441~0.933,P均< 0.05),两者均与弹性系数e及CC呈负相关(P < 0.05)。结论:射频超声技术可用于评价糖耐量减低患者的颈动脉血管弹性变化,从而间接判断早期动脉硬化。

    Abstract:

    Objective:To explore the value of ultrasound radio-frequency(RF) data technique in assessing carotid artery elasticity in patients with impaired glucose tolerance. Methods:In this study,58 objects in IGT group and 39 objects in the control group were included. All patients received ultrasound RF-data technique examination on the carotid artery. The following elastic parameters:intima-media thickness(IMT),vascular expansibility(e),compliance coefficient(CC),stiffness parameter(β),pulse wave velocity(PWV) were obtained. The correlation of them and the differences among the parameters were analyzed. Results:①Compared with normal control group,BMI,2-hPG,TC,TG of IGT group were significantly higher in IGT group(P < 0.05);② IMT,-茁,PWV of IGT group were significantly higher,e,CC were significantly lower in IGT group(P < 0.05);③ In the IGT group,through Pearson correlation analysis,IMT was correlated positively with PWV,age and β(r = 0.290~0.661,all P < 0.05),and PWV was correlated positively with age,IMT and β(r = 0.441~0.933,all P < 0.05). IMT and PWV were correlated negatively with e,CC(P < 0.05). Conclusion:Ultrasound radio-frequency(RF) data technique can evaluate carotid artery elasticity in patients with impaired glucose tolerance,and it should be indicators in the diagnosis of early atherosclerosis.

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王 慧,林红军,俞飞虹.射频超声技术评价糖耐量减低患者颈动脉弹性的临床研究[J].南京医科大学学报(自然科学版),2013,(6):820-823

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  • 收稿日期:2013-02-11
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  • 在线发布日期: 2013-06-25
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