非小细胞肺癌的脉管内侵犯与微转移、微血管密度关系的研究
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目资助(81201830)


Microvessel density and micrometastasis in patients with vascular-invaded non-small cell lung cancer
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:研究非小细胞肺癌微转移与微血管密度的特点,分析肿瘤的脉管内侵犯与微转移-微血管密度之间的关系。方法:采用免疫组化染色方法应用CD34单抗检测47例肿瘤组织的脉管内侵犯及微血管密度;采用RT-PCR技术检测47例患者外周血中CK19 mRNA的表达。结果:47例患者中18例有脉管内侵犯,其平均微血管密度为29.3 ± 3.3,高于非脉管内侵犯的平均微血管密度25.2 ± 4.7(P < 0.05);18例有脉管内侵犯病例中,有13例CK19 mRNA 阳性,5例阴性,29例无脉管内侵犯病例中,9例CK19 mRNA 阳性,20例阴性,具有显著差异性(P < 0.05)。脉管内侵犯与年龄-肿瘤大小-分化程度无关(P > 0.05),而与肿瘤的胸膜浸润-淋巴结转移及远处转移密切相关(P < 0.05)。结论:非小细胞肺癌的脉管内侵犯与微转移-微血管密度之间的关系密切,是评估肿瘤生物学行为的重要临床病理特征。

    Abstract:

    Objective:To detect the clinicopathologic characters of micrometastasis and microvessel density(MVD) occur in non-small cell lung cancer(NSCLC),and to explore the correlation among the former factors and those cases with vascular invasion. Methods:Vascular invasion and MVD was recorded by immunochemistry staining to CD34. Blood samples from 47 patients were examined for CK19 mRNA expression by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Results:Serum CK19 mRNA positive was recorded in 13/18 cases with vascular invasion versus 9/29 in cases without invasion,with statistically difference. The average MVD in the invasion group was (29.3 ± 3.3),higher than the non-invasion group(25.2 ± 4.7). Conclusion:CK19 mRNA positive,pleura invasion,lymphnode state,metastasis and MVD are significantly correlated with vascular invasion in NSCLC patients,and these factors could be used to assess biological behavior of NSCLC.

    参考文献
    相似文献
    引证文献
引用本文

张静渊,尹 荣,徐新宇.非小细胞肺癌的脉管内侵犯与微转移、微血管密度关系的研究[J].南京医科大学学报(自然科学版),2013,(7):887-891

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2013-01-17
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2013-07-09
  • 出版日期:
通知关闭
郑重声明