南京市新生儿出生体重与IGFⅠ、IGF Ⅱ基因多态性的关系分析
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Analysis on association of birth weight with polymorphisms in the IGF I,IGF II genes among Nanjing newborns
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    摘要:

    目的:探讨胰岛素样生长因子Ⅰ(insulin-like growth factorⅠ,IGFⅠ)-胰岛素样生长因子Ⅱ(insulin-like growth factor Ⅱ,IGFⅡ)基因多态性与新生儿出生体重的关系,为不同遗传因素的人群提出合理的干预和建议提供理论基础。方法:采用病例对照的研究方法,在南京地区收集小于胎龄儿(small for gestational age,SGA)88例-适于胎龄儿(appropriate for gestational age,AGA)477例和大于胎龄儿(large for gestational age,LGA)265例组成病例对照,采用PCR-RFLP方法检测IGFⅠrs35767-IGFⅡ rs3741205的基因多态性,采用多因素Logistic回归计算SGA-LGA的相对危险度。结果:IGF I rs35767的TT基因型-CT/TT联合基因型均能显著降低SGA的发病风险(P值分别为0.024,0.031),而未发现IGFⅡ rs3741205与SGA的发生有相关性;IGFⅠ rs35767的CT基因型和IGFⅡ rs3741205的TT基因型都能显著增加LGA的发病风险(P值分别是0.045,0.029)。分层分析结果显示IGFⅡ rs3741205的GT/TT基因型在母亲文化程度为大专及以上的情况下,可使LGA的发病风险降低。结论:IGFⅠ rs35767与SGA的发生相关;IGFⅠ rs35767-IGFⅡ rs3741205与LGA的发生相关。

    Abstract:

    Objective:To investigate the relationship between gene polymorphisms of IGFⅠ,IGFⅡ and birth weight. Methods:In the case-control study,88 small for gestational age infants(SGA),477 appropriate for gestational age infants (AGA) and 265 large for gestational age infants(LGA) were chosen in Nanjing. All the neonates were genotyped for genetic polymorphisms in the IGFⅠ rs35767 and IGFⅡ rs3741205 by using a polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) assay. Linear regression models were used to estimate the association of the genetic polymorphism with LGA and SGA. Results:TT and CT/TT genotype of IGFⅠ rs35767 reduced the risk of SGA significantly(P = 0.024,P = 0.031),the polymorphism in IGFⅡ rs3741205 had no relationship with SGA;CT genotype of IGFⅠ rs35767 and TT homozygote of IGFⅡ rs3741205 increased the risk of LGA significantly(P = 0.045,P = 0.029). When mother’s educational background beyond the college,the IGFⅡ rs3741205 GT/TT genotype reduced the risk of LGA. Conclusion:IGFⅠ rs35767 is contribute to SGA. IGFⅠ rs35767,IGFⅡ rs3741205 are contribute to LGA.

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吉 昕,敖淑清,陆晓梅,刘缌浚,徐济达.南京市新生儿出生体重与IGFⅠ、IGF Ⅱ基因多态性的关系分析[J].南京医科大学学报(自然科学版),2013,(7):964-969

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  • 收稿日期:2013-04-13
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  • 在线发布日期: 2013-07-09
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