TRAF1-C5基因rs3761847位点多态性与东亚人群类风湿性关节炎关联性的Meta分析
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国家自然科学基金资助(30901800)


The association between TRAF1-C5 gene rs3761847 polymorphism and rheumatoid arthritis in East Asian populations:a meta-analysis
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    摘要:

    目的:探讨肿瘤坏死因子受体相关因子1-补体C5(TRAF1-C5)基因rs3761847位点多态性与东亚人群类风湿性关节炎(RA)的关联性。方法:双人同时检索PubMed-EMBase-中国生物医学文献服务系统数据库-中国知网及万方数据库,筛选出有关TRAF1-C5基因与东亚人群RA的病例对照研究,使用STATA软件进行数据分析,计算等位基因A与G-纯合子(AA与GG)-杂合子(GA与GG)-显性模型(GA + AA与GG)-隐性模型(AA与GA + GG)与东亚人群RA关联性的OR值,同时进行异质性分析及亚组分析。结果:纳入符合入选标准的文献5篇,共包括病例组7 438例及对照组5 593例。Meta分析结果表明rs3761847位点多态性与东亚人群RA无明显关联性,但I2 > 50%,存在异质性,故使用亚组分析,发现中国及日本人群的RA与rs3761847位点多态性具有关联性,但未在韩国人群发现这种关联性。结论:TRAF1-C5基因rs3761847位点多态性与中国及日本人群的RA存在关联性,但整体东亚人群是否与之关联仍需多中心-大样本-同质性的病例对照研究。

    Abstract:

    Objective:To explore the association of tumor necrosis factor receptor associted factor 1-complement 5(TRAF1-C5) rs3761847 polymorphism with rheumatoid arthritis (RA) susceptibility in East Asian. Methods:We searched all the publications about the association between TRAF1-C5 polymorphism and RA in East Asian population from PubMed,EMBase,SinoMed,CNKI and Wanfang. Meta-analysis was performed for A allele versus G allele,genotypes AA versus GG,GA versus GG,AA versus GG + GA and GA + AA versus GG using the Stata 10.0 software. OR with the association was obtained from the meta-analysis. Then heterogeneity and stratified analysis were conducted in the study. Results:A total of five eligible studies with 7 438 cases and 5 593 controls were included in this meta-analysis. No significant association was found between TRAF1-C5 polymorphism and RA in East Asian population. However,there is heterogeneity (I2 > 50%),then stratified analysis is used. When analyses were limited to country homogeneous population,significant association was found in Chinese and Japanese population,but not found in South Korea population. Conclusion:This meta-analysis demonstrates significant association between TRAF1-C5 polymorphism and RA in Chinese and Japanese population. More multi-center,large sample,homogeneity case-control studies are still needed to explore the association of TRAF1-C5 polymorphism with RA susceptibility in East Asian.

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惠宇坚,吴东迎,范卫民,胡 军. TRAF1-C5基因rs3761847位点多态性与东亚人群类风湿性关节炎关联性的Meta分析[J].南京医科大学学报(自然科学版),2013,(9):1318-1322

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  • 收稿日期:2013-03-27
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  • 在线发布日期: 2013-09-18
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