甲磺酸桂哌齐特对缺血再灌注脑损伤大鼠的保护作用
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Protection effects of methanesulfonic acid cinepazideon on brain ischemia reperfusion in rats
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    摘要:

    目的:观察甲磺酸桂哌齐特对大鼠缺血性脑损伤保护作用。方法:线拴法建立大鼠大脑中动脉阻塞(MCAO)再灌注损伤模型,72只雄性SD大鼠随机分为6组:假手术组-模型组-甲磺酸桂哌齐特组(20-40-80 mg/kg)和马来酸桂哌齐特组,观察药物对脑缺血再灌注大鼠的血栓形成-血小板聚集-脑梗死体积和对脑组织病理形态学变化的影响。结果:与模型组比较,甲磺酸桂哌齐特(40-80 mg/kg)可减少缺血再灌后脑梗死体积,抑制血栓形成和血小板聚集(P < 0.05);同时可减轻脑组织神经元核固缩-溶解和脑细胞肿胀。与马来酸桂哌齐特相比无明显差异。结论:甲磺酸桂哌齐特对局灶性脑缺血再灌注损伤有保护作用。

    Abstract:

    Objective:To observe the protective effect of methanesulfonic acid cinepazideon(CMI) on cerebral ischemia reperfusion injury in rats. Methods:The local cerebral ischemia/reperfusion model was established by intraluminal thread occlusion of the middle cerebral artery occlusion (MCAO) in rats. Seventy-two male SD rats were randomly divided into five groups:model group,sham group,CMI treatment group (20,40,80 mg/kg) and cinepazide maleate treatment group (40 mg/kg). Thrombosis,platelet aggregation,the infraction volume and pathomorphological changes of brain tissue were observed in each group. Results:Compared with model group,CMI could reduce infract volume,thrombosis and inhibit platelet aggregation (P < 0.05). Also it could reduce neurons karyopyknosis,dissolution and swelling of the brain cells. And the effects had no difference with cinepazide maleate. Conclusion:CMI has a marked neuroprotective effect on local cerebral ischemia reperfusion injury in rats.

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邹浩军,林莉莉,孙雪竹,魏 伟.甲磺酸桂哌齐特对缺血再灌注脑损伤大鼠的保护作用[J].南京医科大学学报(自然科学版),2013,(10):1396-1399

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  • 收稿日期:2012-12-12
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  • 在线发布日期: 2013-10-23
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