COX-2与MVD在三阴性乳腺癌中的表达及相关性研究
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Expression and correlation of COX-2 and MVD in triple-negative breast carcinoma
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    摘要:

    目的:研究COX-2在三阴性乳腺癌中的表达及意义,探讨COX-2与CD31标记的新生微血管密度(MVD)的相关性。方法:采用免疫组化法检测60例三阴性乳腺癌及518例非三阴性乳腺癌组织石蜡标本中的COX-2和MVD的表达情况,并对三阴性乳腺癌与非三阴性乳腺癌的临床病理特征进行比较。结果:①与非三阴性乳腺癌组相比,三阴性乳腺癌组患者年龄偏轻-绝经前患者比例明显升高;三阴性乳腺癌组织分化程度低,组织学分级为 Ⅲ 级的比例明显升高;②COX-2在三阴性乳腺癌及非三阴性乳腺癌组织中的阳性率分别为73.3%-58.0%,两者存在差异(P < 0.05);③三阴性乳腺癌的MVD为183.73 ± 25.64,非三阴性乳腺癌组织中MVD为168.84 ± 24.07,两者间具有显著差异(P < 0.01);④COX-2与MVD在三阴性乳腺癌中的表达具有显著相关性(P < 0.01)。结论:三阴性乳腺癌组织分化差,恶性程度高,COX-2表达和MVD在三阴性乳腺癌中显著增高,两者可能共同参与三阴性乳腺癌的发生-发展,检测COX-2和MVD可作为反映三阴性乳腺癌临床及病理学特点的参考指标,同时可考虑将COX-2作为三阴性乳腺癌治疗的新靶点。

    Abstract:

    Objective:To study the expression and significance of COX-2 in triple-negative breast carcinoma(TNBC) and explore the relevance of COX-2 and neovascularization(MVD) marked by CD31. Methods:The expression of COX-2,MVD in 60 TNBC cases and 518 paraffin wax samples of non-TNBC patients were detected by immuno-histochemical method,and the clinical characteristics of TNBC cases and non-TNBC cases were compared. Results:①Compared with non-TNBC patients,TNBC cases were younger and mostly premenopausal patients,the differentiation of TNBC was lower while the percentage of histology graded Ⅲ was significantly increased;②The positive rate of COX-2 in 60 cases of TNBC was 73.3%,and that in 518 cases of the non-TNBC was 58.0%. The difference is statistically significant(P < 0.05);③In 60 cases of TNBC,the value of MVD(CD31 marked)was 183.73 ± 25.64,in 518 cases of non-TNBC,MVD was 168.84 ± 24.07(P < 0.01);④The expression of COX-2 in TNBC was significantly correlated with CD31(P < 0.01). Conclusion:The high expression of COX-2 and MVD are closely associated with infiltration and metastasis of TNBC,thus the abnormal expression of COX-2 and MVD are likely to participate together in the genesis and progress of TNBC.

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谢智惠,王 蕾,吕 庆,金琳芳,陈 进. COX-2与MVD在三阴性乳腺癌中的表达及相关性研究[J].南京医科大学学报(自然科学版),2013,(10):1410-1414

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  • 收稿日期:2012-11-18
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  • 在线发布日期: 2013-10-23
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