T1非小细胞肺癌淋巴结转移规律及临床意义
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中华国际医学交流基金(CIMF-F-H001-244)


Clinical analysis of lymph nodes etastasis in T1 non-small cell lung cancer
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    摘要:

    目的:探讨T1非小细胞肺癌(NSCLC)淋巴结转移的规律和特点。方法:回顾性分析2011年1月~2012年11月276例行手术治疗T1 NSCLC患者的临床资料,分析淋巴结分布情况及临床病理特征并进行统计学分析。结果:① 276例中66例经病理证实伴淋巴结转移,转移率为23.9%(66/276),高-中低分化NSCLC的胸腔内淋巴结转移率分别为6.1%和33.7%,差异显著(P < 0.05);②右肺中叶较右肺上叶-左肺下叶更易发生胸腔内淋巴结转移(χ2 = 5.545,P < 0.05和χ2 = 5.402,P < 0.05)。66例淋巴结转移患者中,各肺叶肿瘤均存在淋巴结跳跃性转移,但无明显统计学差异。结论:在T1 NSCLC中,右肺中叶较易发生胸腔内淋巴结转移,肺癌淋巴结转移频度与肿瘤分化程度相关,且存在跳跃式转移的特点,故针对T1 NSCLC行肺切除术时施行系统性纵隔淋巴结清扫是非常必要的。

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    Objective:To investigate the characteristics of lymph nodes metastasis in T1 non-small cell lung cancer(NSCLC).Methods:The clinical data of 276 cases underwent resection of NSCLC from January 2011 to November 2012 were analyzed retrospectively. Characteristics of tumors,lymph nodes involvement were analyzed in those cases. Results:①In all 276 cases,66 cases were confirmed pathology with lymph node metastasis,metastasis rate was 23.9%(66/276). The metastatic rates in group of well differentiated and poorly differentiated were 6.1% and 33.7% respectively,the difference being significant(P < 0.05). ② The frequency of metastasis was higher in patients with a primary tumor in the right middle lobe compared to the right upper and left lower lobe(χ2 = 5.545,P < 0.05 and χ2 = 5.402,P < 0.05). Conclusion:In T1 NSCLC,lymph nodes metastatic rate is closely related with the degree of tumor differentiation. The frequency of metastasis was higher in patients with a primary tumor in the right middle lobe. It is necessary to perform systematic node dissection during pulmonary resection for those patients.

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甄福喜,张 憬,王 俊,赵 飞,陈海兵,陈 亮. T1非小细胞肺癌淋巴结转移规律及临床意义[J].南京医科大学学报(自然科学版),2013,(10):1419-1421

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  • 收稿日期:2013-05-22
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  • 在线发布日期: 2013-10-23
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