Addenbrooke改良认知评估量表在帕金森病患者认知障碍的价值初探
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国家自然科学基金(81271211,30700248);科技部重大新药创制(2012ZX09303005-002,2012ZX09303-003);江苏省神经退行性疾病重点实验室开放课题(SJ11KF05);江苏省卫生厅预防医学课题(YZ201022);江苏省科技支撑计划(社会发展)项目(BE2011614);江苏省六大人才高峰项目(WSN-002);南京市科技局国际联合研究项目 (201201106);南京市医药科技发展项目(YKK10113)


Preliminary study on application of the Addenbrooke’s cognitive examination-revised to assessment of cognition in Parkinson’s disease
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    摘要:

    目的:应用Addenbrooke改良认知评估量表(ACE-R)探讨帕金森病(PD)患者认知功能障碍情况。方法:对某三甲专科医院神经科门诊及住院治疗的24例PD患者行ACE-R评估。结果:24例PD中11例简易智能状态检查量表(mini-mental state examination,MMSE)异常与13例MMSE正常的患者比较,两组在年龄方面差异有显著性(P < 0.05),而在病程-Hoehn-Yahr分期及UPDRS-motor方面差异无显著性;24例PD中14例ACE-R异常与10例ACE-R正常的患者比较,两组间年龄差异无显著性,而在病程-Hoehn-Yahr分期及UPDRS-motor方面差异均有显著性(P < 0.05)。两组在ACE-R各分项中(注意和定向-记忆-语言流利性-语言及视空间)差异显著(P < 0.005)。结论:ACE-R用作评估PD合并认知障碍的敏感性高于MMSE,较MMSE更适合用于PD患者的认知障碍筛查。

    Abstract:

    Objective:To investigate the application of the Addenbrooke’s cognitive examination-revised(ACE-R) to the assessment of global cognition in Parkinson’s disease(PD). Methods:Twenty-four PD patients were included. Their cognitive functions were assessed according to the ACE-R scales. Results:Compared with 11 cases of abnormal MMSE scores and 13 cases of normal MMSE scores in 24 cases of PD patients,the age was significantly different in 2 groups with MMSE(P < 0.05),but the duration of symptoms,Hoehn-Yahr stage and UPDRS-motor were not significantly different. Compared with 14 cases of abnormal ACE-R scores and 10 cases of normal ACE-R scores in 24 cases of PD patients,the duration of symptoms,Hoehn-Yahr stage and UPDRS-motor were significantly different in 2 groups with ACE-R (P < 0.05),but the age was not significantly different. The scores of five cognitive subdomains in ACE-R(attention and concentration,memory,verbal fluency,language and visuospatial) in 2 groups with ACE-R were significantly different(P < 0.005). Conclusion:The ACE-R has higher sensitivity than the MMSE for cognitive assessment in PD patients. The ACE-R is more suitable than the MMSE as a cognitive screening tool for PD patients.

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蔡 荇,韦存胜,顾小花,程欣欣,张楚楚,王江波,孙 琦,顾 昊,徐 俊. Addenbrooke改良认知评估量表在帕金森病患者认知障碍的价值初探[J].南京医科大学学报(自然科学版),2013,(10):1422-1425

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  • 收稿日期:2013-07-29
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  • 在线发布日期: 2013-10-23
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