新诊断的1型糖尿病患者血清25-羟维生素D3水平与锌转运8自身抗体的相关性研究
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金资助(30671010, 30971405)


The correlation study of serum 25-hydroxyvitamin D3 and zinc transporter 8 antibodies in newly diagnosed type 1 diabetes mellitus
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨血清25-羟维生素D3[25(OH)D3)]水平与新诊断的1型糖尿病(T1DM)锌转运8自身抗体(ZnT8A)的关系。方法:选取初发的T1DM患者32例,100例健康者为正常对照组。对每位患者进行临床资料收集及常规生化指标-血清25(OH)D3水平-ZnT8A抗体的检测;分析血清25(OH)D3水平与ZnT8A抗体滴度的关系。结果:①与正常对照组的血清25(OH)D3水平[(69.4 ± 9.2)nmol/L]比较,T1DM组的血清25(OH)D3水平[(36.8 ± 6.1)nmol/L]显著降低(P < 0.01);在维生素D缺乏人群中,T1DM的患病风险增加(OR = 3.16,95%CI:3.02~3.31);②根据25(OH)D3水平由高到低分为3组,结果发现空腹及餐后C肽水平逐渐降低(P < 0.05);与维生素D充足组比较,维生素D缺乏组Zn8TA阳性率升高(P < 0.05);③ZnT8A阳性率与25(OH)D3水平负相关(r = -1.036,P < 0.05)。结论:①T1DM患者血清25(OH)D3水平较低,维生素D缺乏的人群T1DM的患病风险增高;②血清25(OH)D3水平可能影响ZnT8A阳性率。

    Abstract:

    Objective:To evaluate the association of 25-hydroxyvitamin D3[25(OH)D3]and zinc transporter 8 antibodies(ZnT8A) in newly diagnosed type 1 diabetes mellitus(T1DM). Methods:There were 32 newly diagnosed type 1 diabetes mellitus and 100 controls in this study. Clinical data were collected,biochemical parameters,serum 25 (OH)D3 levels and ZnT8A were detected;the relevance of serum 25(OH)D3 and ZnT8A were analyzed. Results:①Serum 25(OH)D3 level was significantly lower in T1DM than that in the controls(P < 0.01). In the vitamin D deficiency group,the prevalence of T1DM was increased,risk odds ratio (OR = 3.16,95% confidence region:3.02~3.31).②From vitamin D sufficient group to vitamin D deficient group,fasting and postprandial C-peptide level were gradually decreased(P < 0.05);the ZnT8A positive rate in vitamin D deficient group was higher than vitamin D sufficient group (P < 0.05).③The ZnT8A positive rate was negatively related with serum 25(OH)D3 concentrations(r = -1.036,P < 0.05). Conclusion:①The serum 25(OH)D3 level in T1DM was significantly lower than that in the controls. The T1DM patients are at risk for vitamin D insufficiencies. ②There was interaction between the serum 25(OH)D3 concentration and ZnT8A.

    参考文献
    相似文献
    引证文献
引用本文

罗 娜,杨 涛,王知笑,张真稳,王 艳,朱 妍.新诊断的1型糖尿病患者血清25-羟维生素D3水平与锌转运8自身抗体的相关性研究[J].南京医科大学学报(自然科学版),2013,(10):1430-1434

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2013-06-20
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2013-10-23
  • 出版日期:
通知关闭
郑重声明