糖尿病合并非酒精性脂肪肝多因素分析
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Multi-factors analysis in patients with type 2 diabetes with non alcoholic fatty liver disease
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    摘要:

    目的:探讨2型糖尿病(T2DM)并发非酒精性脂肪肝(NAFLD)的发病因素。方法:分别采用酶联免疫吸附(ELISA)法和化学发光法检测45例单纯T2DM-44例T2DM + NAFLD患者和24例对照组血清细胞角蛋白18(CK18)-游离脂肪酸(FFA)-肿瘤坏死因子α(TNF-α)-超氧化物歧化酶(SOD)水平,同时检测和计算研究组和对照组的体质指数(BMI)-胰岛素抵抗指数(HOMA-IR)-空腹血糖(FPG)等一般生理生化指标,进行t检验-相关分析和二元Logistic回归等统计学分析。结果:NAFLD与BMI-HOMA-IR-FPG-TC-TG-AST-ALT-GGT-FFA-CK18-TNF-α呈正相关;与SOD呈负相关;与FINS-HbA1c无相关;BMI-HOMA-IR-FFA-CK18与NAFLD病因高度相关。结论:NAFLD的发病是多重因素共同作用的结果,其中BMI-HOMA-IR-FFA-CK18为NAFLD发病的独立危险因素。

    Abstract:

    Objective:To explore the risk factors of patients with type 2 diabetes mellitus (T2DM ) with non-alcoholic cirrhosis (NAFLD). Methods:The enzyme-linked immunosorbent assay (ELISA) and chemiluminescene analyzer were used to detect the serum cytokeratin 18(CK18),free fatty acids (FFA),tumor necrosis factor alpha (TNF-α),superoxide dismutase enzyme (SOD) in 45 cases of T2DM,44 cases of T2DM+NAFLD patients and 24 cases of control. Body mass index(BMI),insulin resistance index(HOMA-IR),fasting plasma glucose (FPG) and general physiological and biochemical indexes of the study group and the control group were simultaneously detected and calculated,and their correlation with NAFLD was analyzed by correlation analysis and binary logistic regression statistical analysis. Results:BMI,HOMA-IR,FPG,TC,TG,AST,ALT,GGT,FFA,CK18 and TNF-α were positively related with NAFLD. SOD was negatively related with NAFLD. FINS and HbA1c have no relation with NAFLD. BMI,HOMA-IR,FFA and CK18 were highly related with etiology of NAFLD. Conclusion:The pathogenesis of NAFLD is the result of multiple factors. The BMI,HOMA-IR,FFA and CK18 is independent risk factor of the NAFLD.

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杨士军,陆卫平,吴 茜,谷 静.糖尿病合并非酒精性脂肪肝多因素分析[J].南京医科大学学报(自然科学版),2013,(10):1439-1441

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  • 收稿日期:2012-12-13
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  • 在线发布日期: 2013-10-23
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