FAT4基因功能性单核苷酸多态性和中国江苏人群胃癌易感性相关
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国家自然科学基金(81001276?81072380);江苏省自然科学基金(BK2008221)


Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of gastric cancer in a Jiangsu population
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    摘要:

    目的:探讨FAT4基因单核苷酸多态性与江苏人群胃癌遗传易感性的关系。方法:采用人群为基础的病例对照研究对来自江苏的783例经组织病理学确诊的胃癌新发病例和按照性别年龄匹配的855例健康对照,利用实时荧光定量PCR(real-time PCR)方法对FAT4基因上非同义氨基酸多态性位点进行基因分型,比较各位点不同基因型与胃癌发病风险的关系。结果:利用Logistic回归模型在相加模型中进行了分析的结果显示,在调整性别-年龄-吸烟和饮酒等因素后,携带rs1039808 A等位基因的个体胃癌发病风险显著低于携带野生纯合子(GG)的个体(OR = 0.74,95%CI:0.62~0.88,P = 0.001)。分层分析显示,在各亚组间rs1039808不同基因型与胃癌发病风险的关联强度没有显著差异。结论:FAT4基因单核苷酸多态性rs1039808 A等位基因能显著降低胃癌发病风险。

    Abstract:

    Objective:To investigate the association between nonsynonymous polymorphisms (rs1039808,rs12508222,rs1567047 and rs1014867) in FAT4 gene and the risk of gastric cancer. Methods:A case-control study of 783 gastric cancer cases and 855 controls was conducted in a Chinese population of Jiangsu Province using the TaqMan allelic discrimination assay on the ABI 7900 system. Results:We found that A allele of rs1039808 (Ala807Val) was significantly associated with a decreased risk of gastric cancer risk in additive model after adjusted by age,sex,smoking and drinking status (OR = 0.74,95%CI:0.62~0.88,P = 0.001). Similar association strengths were shown between all subgroups for rs1039808(P>0.05 for heterogeneity test). Conclusion:These findings indicate that the nonsynonymous variants rs1039808 (Ala807Val) of FAT4 may contribute to gastric cancer susceptibility in a Chinese population of Jiangsu Province.

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成建国,朱 陈,杜江波,戴宁彬,胡志斌. FAT4基因功能性单核苷酸多态性和中国江苏人群胃癌易感性相关[J].南京医科大学学报(自然科学版),2013,(11):1638-1642

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  • 收稿日期:2013-05-16
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  • 在线发布日期: 2013-11-25
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