Objective:To establish a rat model of inferior vena cava thrombosis,and to summarize the process of modeling techniques and surgical considerations. Methods:A total of 82 healthy SD rats were divided into the control group and the model group. The model group was adopted a ＂stenosis technology＂,which blocked most of blood flow in the inferior vena cava. At determined time points after ligation,laparotomy was performed and tissues were observed and sampled for pathological examination to evaluate modeling success. Results:Both of the two groups survived during the whole experiment and there were no accidental death,with the survival rate of 100%. The control group had no inferior vena cava thrombosis(0/8);in the Model group,thrombosis(6/8,75%)was found after two hours of surgery,and it was visible after 6 hours(8/8,100%). Between 24 to 48 hours after surgery,a stable thrombus formed with a lumen hyperemia(16/16,100%). After 7 days,organic thrombus was observed,but there was no significant regression(8/8,100%). The dissolving thrombus regression was observed between 14 to 21 days after surgery(16/16,100%). Conclusion:The stenosis technology can be used to block inferior vena cava blood flow successfully to establish the inferior vena cava thrombosis model.