江苏省两县柯萨奇病毒A组16型流行病学特征分析
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国家科技部支撑计划十二五重大专项


Analysis of epidemiological characteristics of Coxsakievirus A16 in two counties in Jiangsu Province
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    摘要:

    目的:探讨柯萨奇病毒A组16型(CVA16)的流行病学特征,以期为手足口病的综合防治和CVA16疫苗研制提供流行病学依据-方法:基于在江苏建立的肠道病毒所致疾病监测系统,通过主动与被动报告相结合的方式对东海县2 875人-宝应县2 080人进行监测;使用统一调查表格对病例进行个案调查,并采集咽-肛拭子进行实时荧光定量PCR法快速检测-结果:截至2013年2月,东海-宝应两县CVA16感染所致发病率分别为16.73%(481/2 875)和9.28%(193/2 080), 整个监测期间均只出现1个发病高峰,均在2012年5月中下旬;两县病例均覆盖所有乡镇,但不同乡镇间发病率存在地区差异;两县所发现病例年龄范围为9~42月龄,男-女性别比分别为1.59∶1和1.47∶1,不同性别发病率无统计学差异-结论:2012年3月~2013年2月江苏省东海和宝应两县肠道病毒流行以CVA16为主,病毒流行具有明显的季节性以及地区差异性-

    Abstract:

    Objective:To investigate the epidemiological characteristics of Coxsakievirus A16 (CVA16),and thus lay foundation for the comprehensive prevention and control of hand, foot and mouth diseases and development of CVA16 vaccines. Methods:Based on the active and passive surveillance systems built for enterovirus disease,we performed a surveillance of CVA16-associated diseases among 2 875 and 2 080 infants and young children from Donghai county and Baoying county,respectively,from March,2012 to February,2013. A unify investigation form was used to collect related information of CVA16-associated cases, and a series of throat and anal swabs were collected for real-time fluorescent quantitative PCR assay. Results:During the whole surveillance period, the incidence rates of CVA16-associated diseases were 16.73%(481/2 875) for Donghai County and 9.28%(193/2 080) for Baoying County. Only one peak of incidence, which occurred in May,2012,was observed in both counties. The addresses of reported CVA16-associated cases covered all towns in both two counties, but the incidence was different among different towns. All of the reported cases aged between 9 and 42 months. Although the sex ratios(male: female) were 1.59∶1 and 1.47∶1 for Donghai County and Baoying County,respectively,there was no significant difference of incidence between male and female in both two counties. Conclusion:From March,2012 to Feburary,2013,CVA16 was the major prevalent enterovirus in Donghai County and Baoying County in Jiangsu Province. The prevalence of CVA16 showed an obvious seasonal trend and regional difference.

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陆晓芳,朱凤才,孟繁岳,张雪峰,李靖欣.江苏省两县柯萨奇病毒A组16型流行病学特征分析[J].南京医科大学学报(自然科学版),2014,(4):511-515

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  • 收稿日期:2013-07-09
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  • 在线发布日期: 2014-04-18
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