不同类型重症药疹患者外周血淋巴细胞亚群分析及其临床意义
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国家自然科学基金(81171517)


Analysis and clinical significance of lymphocyte subsets in the peripheral blood in patients with different types of severe drug eruption
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    摘要:

    目的:检测不同类型重症药疹患者外周血淋巴细胞亚群并研究其临床意义-方法:采用免疫荧光标记流式细胞术检测21例重症药疹患者外周血淋巴细胞的表型-结果:药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)患者治疗前CD3+-CD3+CD4+淋巴细胞较正常值显著增加,并且DIHS患者治疗前CD3+CD4+淋巴细胞显著高于Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)和中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)患者;在SJS和TEN患者中,随着外周血CD3+CD4+-CD3+CD8+淋巴细胞数目的增加,激素最大控制用量逐渐减少,随着外周血CD3-CD16+CD56+淋巴细胞数目的增加,激素最大控制用量逐渐增加-结论:不同类型的重症药疹外周血淋巴细胞亚群不同,外周血不同类型淋巴细胞亚群对激素最大控制用量的影响不同-

    Abstract:

    Objective:To detect lymphocyte subsets in the peripheral blood of patients with different types of severe drug eruption and study its clinical significance. Methods:Immunofluorescence flow cytometry was performed to analyze the phenotypes of peripheral blood cells in 21 patients with severe drug eruption. Results:CD3+,CD3+CD4+ lymphocytes of the peripheral blood in drug-induced hypersensitivity syndrome (DIHS) patients was significantly increased in comparison with the normal value,and CD3+CD4+ lymphocytes of the peripheral blood cells in DIHS patients was significantly higher than that in Stevens-Johnson Syndrome (SJS) patients and toxic epidermal necrolysis (TEN) patients. With the increase in the number of CD3+CD4+ and CD3+CD8+ lymphocytes in the peripheral blood cells,the maximum dosage of corticosteroids progressively decreased in SJS and TEN patients. With the increase in the number of CD3-CD16+CD56+ lymphocytes of the peripheral blood cells,the maximum dosage of corticosteroids progressively increased in SJS and TEN patients. Conclusion:Different types of severe drug eruption have different lymphocyte subsets in the peripheral blood,which have different effects on the maximum dosage of corticosteroids.

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孙 杰,张锦英,丁高中,龚晴丽,鲁 严.不同类型重症药疹患者外周血淋巴细胞亚群分析及其临床意义[J].南京医科大学学报(自然科学版),2014,(6):777-781

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  • 收稿日期:2014-01-27
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  • 在线发布日期: 2014-06-19
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