Objective:To explore the relationship between C－reactive protein (CRP) elevation,overweight,obesity as well as their interactions and diabetes risk. Methods:Stratified cluster sampling method was and 2 400 residents aged over 40 years were selected. A pre－tested questionnaire was performed to collect the demographic information,lifestyle,history of disease,family history of diabetes and etc. Anthropometric measurements including height,weight,wait circumference (WC) and blood pressure (BP) were performed at the time of interview. Fasting blood sample was also collected for the detection of CRP,fasting blood glucose (FBG) and etc. Logistic regression method was applied to evaluate the relationship between CRP elevation (> 3 mg/L),overweight,obesity and diabetes risk. Odds ratio (OR) and 95% confidence interval (CI) were calculated. Interactions were estimated on both additive scale and multiplicative scale. Results:A total of 1 899 subjects were interviewed and recruited for the analysis,the responding rate was 79.13%. Among them,238 type 2 diabetes cases were identified. Comparing with the normal level (CRP≤3 mg/L),the adjusted OR for CRP elevation with diabetes (CRP> 3 mg/L) was 1.74 (95%CI:1.24~2.45);the OR for high WC,BMI getting overweight and obesity was 1.41 (95%CI:1.06~1.89),1.70 (95%CI:1.12~2.44) and 2.22 (95%CI:1.39~3.54),respectively. Individuals with elevated CRP level,overweight or obesity were at the highest risk of diabetes,whereas no significant interaction was observed. Conclusion:High CRP level,overweight and obesity are associated with increased risk of type 2 diabetes. Reducing CRP,BMI and WC level through interventions may postpone or reduce the development of type 2 diabetes.