花生四烯酸对小鼠卵泡衰老的影响
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家重大科学研究计划(2013CB945200):国家自然科学基金面上项目 (81170780,81372798,81200570);教育部博士学科点基金(20113234110005);江苏省科技支撑计划(BE2012756);江苏省自然科学基金(BK20130059,BK2011766)


Effects of arachidonic acid on follicle failure of mice
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:研究花生四烯酸(arachidonic acid,AA)对小鼠卵泡发育的影响,探讨AA与卵巢早衰的关系-方法:10% AA饲料喂食4周龄ICR雌鼠,4个月后观察小鼠子宫卵巢重量-卵巢组织脂肪酸分析-卵巢组织学改变-结果:10%AA组与对照组相比子宫卵巢体重下降;脂肪酸分析结果显示10%AA组卵巢n-6/n-3不饱和脂肪酸比值增大;光镜下,10%AA组可见卵巢退行性黄体增多-间质纤维化-卵巢闭锁卵泡所占比例增加-结论:喂食10%AA饲料可引起小鼠卵巢衰老-

    Abstract:

    Objective:To investigate the effect of arachidonic acid (AA) on follicle development of female mice and explore the relationship between AA and premature ovarian failure. Methods:ICR female mice of 4-week-old were fed with 10% AA. The weight of uterus and ovary,fatty acid analysis of ovaries,histological changes in ovaries were examined after four months. Results:The uterus and ovary weight of the 10% AA group were lower than those of the control group. Fatty acid analysis showed that the n-6/n-3 ratio of ovaries was increased in the 10% AA group. Under optical microscope,ovaries from the 10% AA group showed increased visible ovarian degenerative corpus luteum,interstitial fibrosis and increased proportion of atretic follicles. Conclusion:10% AA can cause obvious ovarian failure in mice.

    参考文献
    相似文献
    引证文献
引用本文

张 怡,李晓曦,林 艳,毕欣耘,于鹏丽,赵子建.花生四烯酸对小鼠卵泡衰老的影响[J].南京医科大学学报(自然科学版),2014,(9):1202-1205

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2014-03-17
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2014-09-11
  • 出版日期:
通知关闭
郑重声明