Objective:This desigh was based on magnetoresistive sensors, which realized real-time magnetic drug tracking. Methods:Magnetoresistive sensors detect magnetic field signals of the Fe-Fe3O4 core-shell structure nanoparticles which simulate magnetic drug. By conversion processing,spatial information of the magnetic particles can be obtained. Results:A virtual real-time detection system based on LabVIEW can display magnetic particles’ position. Conclusion:Experiments show that the system has good timeliness and accuracy,and can provide a new in vivo detecting approach of clinical studies on magnetic drug.