Objective:To analyze the safety and feasibility in orthotopic liver transplantion without abdominal drainage. Methods:we retrospected drains in 175 patients who did liver transplantation in liver transplantation center from January 2010 to September 2013. Patients were divided into a drainage group (n = 63) and a non-drainage group (n = 112) separately according to the application of abdominal drainage. Preoperative factors,factors during operation,perioperative complications and lengths of stay were analyzed and compared. Results:Preoperative factors of patients showed no significant difference.(P > 0.05) No significant difference was noted in the blocking time of vena cava and portal vein,with bleeding and transfusion condition indicating no significant difference either. Furthermore,no significant deviation was noted regarding to complication grading (P = 0.78) and complications related to abdominal drainage (e.g. bleeding,bile leakage,massive ascites,incision drainage). However,significant deviation was noted in the two groups about lengths of stay in ICU and lengths of stay after operation (P < 0.01). Conclusion:It is feasible and safe for not using abdominal drainage after liver transplantation-