Objective:To investigate the main risk factors of congenital heart disease in Chinese children so as to provide evidences for decision-making on prevention. Methods:The results of 26 studies on risk factors of congenital heart disease were analyzed by meta-analysis. The numbers of cumulative cases and controls were 7 917 and 12 835 respectively. The calculation methods of the merged odds ratio(OR)and 95% confidence interval(CI)were determined according to the homogeneity test. Results:The pooled OR values and 95% CI as follows:spontaneous abortion was 1.69(1.24~2.31);exposure to noise was 1.28(0.39~4.19); fetal abnormality was 2.31(1.25~4.27);medicine use in pregnancy was 1.88(1.57~2.23);exposure to damage chemicals in pregnancy was 3.46 (2.11~5.66);history of consanguineous marriage was 2.88 (1.88~4.40);passive smoking was 1.16 (0.69~1.95);adverse mental stimulus was 2.58 (1.36 ~4.91);father drinking was 1.88 (1.44 ~2.45);cold of early pregnancy was 3.06 (2.17~4.32). Conclusion:The risk factors of congenital heart disease are spontaneous abortion,fetal abnormality,medicine use in early pregnancy,adverse mental stimulus,father’s drinking,history of consanguineous marriage and had a cold during early pregnancy.