中国围产儿先天性心脏病危险因素Meta分析
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省科技厅自然科学基金(BK2011862)


Meta analysis of risk factors of congenital heart disease of Chinese perinatal children
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:系统评价中国围产儿先天性心脏病发生的主要危险因素,为其防治工作提供参考-方法:对国内26篇关于先天性心脏病发病危险因素的研究文献进行Meta分析-累计病例7 964例,对照12 929例-根据齐性检验结果计算各危险因素合并比值比(OR)及其95%可信区间(95%CI)模型-结果:先天性心脏病各危险因素的OR值及95%CI分别为:流产史1.69(1.24~2.31)-环境噪音1.28(0.39~4.19)-孕期检查胎儿异常2.31(1.25~4.27)-孕期服用药物1.88(1.57~2.23)-接触有害物质3.46(2.11~5.66)-近亲婚配史2.88(1.88~4.40)-被动吸烟1.16(0.69~1.95)-孕早期精神因素2.58(1.36~4.91)-父亲饮酒1.88(1.44~2.45)-孕早期感冒3.06(2.17~4.32)-结论:流产史-孕期检查胎儿异常-孕期服用药-早期精神因素-父亲饮酒-近亲婚配和孕早期感冒是先天性心脏病的危险因素-

    Abstract:

    Objective:To investigate the main risk factors of congenital heart disease in Chinese children so as to provide evidences for decision-making on prevention. Methods:The results of 26 studies on risk factors of congenital heart disease were analyzed by meta-analysis. The numbers of cumulative cases and controls were 7 917 and 12 835 respectively. The calculation methods of the merged odds ratio(OR)and 95% confidence interval(CI)were determined according to the homogeneity test. Results:The pooled OR values and 95% CI as follows:spontaneous abortion was 1.69(1.24~2.31);exposure to noise was 1.28(0.39~4.19); fetal abnormality was 2.31(1.25~4.27);medicine use in pregnancy was 1.88(1.57~2.23);exposure to damage chemicals in pregnancy was 3.46 (2.11~5.66);history of consanguineous marriage was 2.88 (1.88~4.40);passive smoking was 1.16 (0.69~1.95);adverse mental stimulus was 2.58 (1.36 ~4.91);father drinking was 1.88 (1.44 ~2.45);cold of early pregnancy was 3.06 (2.17~4.32). Conclusion:The risk factors of congenital heart disease are spontaneous abortion,fetal abnormality,medicine use in early pregnancy,adverse mental stimulus,father’s drinking,history of consanguineous marriage and had a cold during early pregnancy.

    参考文献
    相似文献
    引证文献
引用本文

马丹华,徐厚明,林 宁,喻荣彬,孙晓如,丁克琴,雷 娜.中国围产儿先天性心脏病危险因素Meta分析[J].南京医科大学学报(自然科学版),2014,(9):1273-1278

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2013-06-07
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2014-09-11
  • 出版日期:
通知关闭
郑重声明