α-硫辛酸通过降低氧化应激改善2型糖尿病低血糖脑病的研究
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Investigation on the use of α-lipoic acid for ameliorate hypoglycemic encephalopathy in patients with type 2 diabetes by reducing oxidative stress
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    摘要:

    目的:探讨抗氧化剂α-硫辛酸对2型糖尿病低血糖脑病氧化应激-内皮素-1和神经功能恢复的影响-方法:将60例2型糖尿病低血糖脑病患者随机分为α-硫辛酸治疗组(30例)和对照组(30例),观察两组治疗前后氧化应激标志物丙二醛(malondialdehyde,MDA)-超氧化物歧化酶(superoxide dismutase,SOD)和内皮素-1(endothelin-1,ET-1)的变化,并比较两组治疗前后神经功能损害程度评分的不同-结果:α-硫辛酸组治疗后与治疗前相比较:MDA-ET-1以及神经功能损害程度评分均显著降低(分别为P < 0.01-P < 0.05-P < 0.01),SOD显著增高(P < 0.01)-对照组治疗后与治疗前相比较:MDA与神经功能损害程度评分显著降低(分别为P < 0.05-P < 0.01)-α-硫辛酸组与对照组治疗后相比较,MDA-ET-1及神经功能损害程度评分显著降低(分别为P < 0.05-P < 0.05-P < 0.01),SOD显著增高(P < 0.05)-结论:α-硫辛酸可改善氧化应激及内皮功能,有助于2型糖尿病低血糖脑病的恢复-

    Abstract:

    Objective:To investigate influence of antioxidant α-lipoic acid on oxidative stress, endothelin-1 and recovery of neuronal function in type 2 diabetic patients with hypoglycemic encephalopathy. Methods:A total of 60 type 2 diabetic patients with hypoglycemic encephalopathy were randomly divided to control group (n=30) and α-lipoic acid treatment group (n=30). The differences in malondialdehyde (MDA), superoxide dismutase (SOD) and endothelin-1 (ET-1) were observed between the control group and the α-lipoic acid treatment group before and after treatment. Neurological impairment score was compared between the two groups. Results:The levels of MDA and ET-1 as well as the neurological impairment score were significantly decreased after α-lipoic acid treatment (P < 0.01, P < 0.05 and P < 0.01, respectively), whereas the level of SOD was significantly increased after α-lipoic acid treatment (P < 0.01). The levels of MDA and the neurological impairment score were significantly decreased in the control group after treatment (P < 0.05 and P < 0.01, respectively). Furthermore, there were significant decreases in the levels of MDA And ET-1,neurological impairment score (P < 0.05, P < 0.05 and P < 0.01, respectively), and the level of SOD (P < 0.05) in the α-lipoic acid group compared to the control group after treatment. Conclusion:α-lipoic acid can ameliorate hypoglycemic encephalopathy in type 2 diabetic patients by reducing oxidative stress and improving endothelial function.

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康 健,冯亚敏,萧丽军,唐 莹,祝 群.α-硫辛酸通过降低氧化应激改善2型糖尿病低血糖脑病的研究[J].南京医科大学学报(自然科学版),2014,(11):1534-1537

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  • 收稿日期:2014-06-30
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  • 在线发布日期: 2014-11-21
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