MONW在健康体检人群中的患病率及其与胰岛素抵抗关系的研究
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江苏省人民医院临床诊疗新技术新项目(JSPH-XJS-2012-48)


The study on prevalence of MONW in physical examination people and its relationship with insulin resistance
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    摘要:

    目的:筛查正常体重代谢性肥胖(metabolically obese but normal-weight,MONW)在健康体检人群中的患病率,检测该人群血压-血糖和胰岛素的水平,并探讨内脏脂肪面积(visceral fat area,VFA)与胰岛素抵抗的关系-方法:选取南京医科大学第一附属医院健康管理中心参与人体成分检测的体检人群4 552例,筛查MONW的患病率;并从中随机选取794例同时检测血压(blood pressure,BP)-空腹血糖(fasting blood glucose,FPG)及空腹胰岛素(fasting insulin,FINS),计算胰岛素抵抗指数(HOMA-IR),并分析HOMA-IR与VFA的关系-结果:MONW发病率为11.25%,MONW组血压和空腹胰岛素异常的发生率均高于健康组(P < 0.001),分别为30.11%和3.26%-体质指数(body mass index,BMI)正常或升高组中,VFA≥100 cm2组HOMA-IR均高于VFA<100 cm2组(P < 0.05)-结论:体检人群中MONW比较常见-MONW处于异常代谢状态的比例升高,胰岛素抵抗增加,机制可能与内脏脂肪蓄积有关-

    Abstract:

    Objective:To screen the prevalence of metabolically obese but normal-weight (MONW) in physical examination population,and to detect blood pressure (BP),fasting blood glucose (FPG) and fasting insulin (FINS) of MONW and investigate the correlation between visceral fat area (VFA) and insulin resistance. Methods:A total of 4 552 people,who had underwent investigations for body component measurement in the health management center of the First Affiliated Hospital of NJMU,were chosen to screen the prevalence of MONW. From the 4 552 people,794 were randomly selected to detect BP,FPG and FINS at the same time. We calculated the value of insulin resistance index (HOMA-IR) and analyzed the relationship between HOMA-IR and VFA. Results:The MONW morbidity of the Health Management Center of the First Affiliated Hospital of NJMU was 11.25%. The incidences of abnormal BP and FINS in MONW were 30.11% and 3.26%,respectively,which were both higher than those of the healthy group (P < 0.001). No matter the body mass index (BMI) was in the normal range or abnormal,HOMA-IR of the VFA ≥ 100 cm2 group was higher than that of the VFA < 100 cm2 group (P < 0.05). Conclusion:MONW is common in physical examination people. The proportion of abnormal metabolic state and insulin resistance were increased in MONW. Its mechanism may be related to the accumulation of visceral fat.

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张 群,唐 芳,许年珍,邓红英,马向华,李晓娜. MONW在健康体检人群中的患病率及其与胰岛素抵抗关系的研究[J].南京医科大学学报(自然科学版),2014,(11):1538-1541

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  • 收稿日期:2014-07-29
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  • 在线发布日期: 2014-11-21
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