TNFAIP3、Mn-SOD在放射治疗鼻咽癌中的意义
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湖南省教育厅科学研究项目(11C1162)


Significance of TNFAIP3 and Mn-SOD in radiotherapeutic nasopharyngeal carcinoma
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    目的:研究肿瘤坏死因子α诱导蛋白3(tumor necrosis factor alpha induced protein 3,TNFAIP3)-锰超氧化物歧化酶(Manganese superoxide dismutase,Mn-SOD) mRNA在放射治疗后鼻咽癌中的表达,探讨其在鼻咽癌放射治疗中的意义-方法:运用原位杂交方法检测放射治疗后鼻咽癌中TNFAIP3及Mn-SOD mRNA的表达-结果:TNFAIP3 mRNA中度及强阳性表达率在放疗敏感鼻咽癌中为15.00%,在放疗抗拒鼻咽癌中为45.00%;Mn-SOD mRNA中度及强阳性表达率在放疗敏感鼻咽癌中为55.00%,在放疗抗拒鼻咽癌中为40.00%,差异均有统计学意义(P均< 0.05)-在放疗抗拒鼻咽癌中,TNFAIP3 mRNA中度及强阳性表达率与TNM分期呈正相关,Ⅲ~Ⅳ期表达率为48.28%,Ⅰ~Ⅱ期表达率为36.36%,Mn-SOD mRNA中度及强阳性表达率与T分期呈正相关,T3~T4期中表达率为63.16%,T1~T2期中表达率为19.05%;TNFAIP3 mRNA中度及强阳性表达率在有远处转移的放疗抗拒鼻咽癌中为81.81%,在无远处转移的放疗抗拒鼻咽癌中为31.03%,Mn-SOD mRNA中度及强阳性表达率在有远处转移的放疗抗拒鼻咽癌中为81.82%,在无远处转移的放疗抗拒鼻咽癌中为24.14%,差异均有统计学意义(P均< 0.05)-结论:TNFAIP3参与了放疗抗拒鼻咽癌的发生-发展;Mn-SOD能增加鼻咽癌的放射敏感性,增强放疗鼻咽癌的抗氧化作用-

    Abstract:

    Objective:To study the expressions of tumor necrosis factor alpha induced protein 3 (TNFAIP3) and manganese superoxide dismutase (Mn-SOD) mRNA in radiotherapeutic nasopharyngeal carcinoma,as well as their significances. Methods:In situ hybridization detections were performed to detect the expressions of TNFAIP3 and Mn-SOD in radiotherapeutic nasopharyngeal carcinoma. Results:In radiosensitive and radioresistant nasopharyngeal carcinoma,the moderately and strongly positive TNFAIP3 mRNA expression rates were 15.00% and 45.00%,respectively;the moderately and strongly positive Mn-SOD mRNA expression rates were 55.00% and 40.00%,respectively,and there were statistical significances (both P < 0.05). In radioresistant nasopharyngeal carcinoma,the moderately and strongly positive TNFAIP3 mRNA expression was positively correlated with TNM stage. In III-IV stage and Ⅰ~Ⅱ stage,the moderately and strongly positive expression rates were 48.28% and 36.36%,respectively. The moderately and strongly positive Mn-SOD mRNA expression was positively correlated with T stage. In stage of T3~T4 and T1~T2,the moderately and strongly positive expression rates were 63.16% and 19.05%,respectively. In distant metastasis and no distant metastasis,the moderately and strongly positive TNFAIP3 mRNA expression rates were 81.81% and 31.03%,respectively;the moderately and strongly positive Mn-SOD mRNA expression rates were 81.82% and 24.14%,respectively,and the differences had statistical significance (both P < 0.05). Conclusion:TNFAIP3 gene is correlated with the occurrence and development of radioresistant nasopharyngeal carcinoma. Mn-SOD gene can increase the radiosensitivity of nasopharyngeal carcinoma and the anti-oxidative effect of radioresistant nasopharyngeal carcinoma.

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邓香群,贺印旎. TNFAIP3、Mn-SOD在放射治疗鼻咽癌中的意义[J].南京医科大学学报(自然科学版),2014,(11):1550-1554

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  • 收稿日期:2014-02-25
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  • 在线发布日期: 2014-11-21
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