Objective:To analyze the epidemiological characteristics of syphilis in Qinhuai district of Nanjing,Jiangsu province from 2004 to 2012. Methods:The epidemic data of syphilis from China disease prevention and control information system in Qinhuai district was analyzed by excel 2003 and SPSS 16.0. Results:There were reported a total of 1310 cases of syphilis in Qinhuai distict from 2004 to 2012. In the reported cases of syphilis,early syphilis including primary and secondary syphilis were 71.53%; there were significant differences between the stages of syphilis cases and the different years (P< 0.05); the gender ratio was 0.91∶1.00; there were 676 cases of syphilis were aged from 20 to 39,accounting for 51.60% in total cases of syphilis. Conclusion:The incidence of syphilis in Qinhuai distict was increased from 2004,declined from 2010,and most of cases of syphilis were primary and secondary syphilis,we should strengthen the comprehensive measures of prevention diagnosis and treatment of syphilis,in order to control the spread of syphilis and AIDS.