Objective:To detect the expression of IL-2 receptor β and γ chain(CD122 and CD132) on CD4+CD25-T cells in peripheral blood of systemic tupus erythematosus (SLE)patients and CD4+CD25+T cells which were induced from the former in vitro,as well as assess its effects on the induction of Foxp3+ induced regulatory T cell (iTreg). Methods:Peripheral blood mononuclear cells (PBMCs) were isolated from SLE patients and healthy donors and further isolated CD4+CD25-T cells. The ratio of CD25-CD122+/CD4+,CD25-CD132+/CD4+ and CD122/CD132 (IL-2 receptor β and γ chain) mRNA relative abundance in CD4+CD25-T cells were analyzed by flow cytometry and real-time quantitative PCR,respectively. CD4+CD25-T cells were induced to further analyze the ratio of CD25+CD122+/CD4+,CD25+CD132+/CD4+,CD25+Foxp3+/CD4+,pStat5+/CD4+CD25+. Results:Compared with the normal subjects,there were no significant changes in the expression of CD122 on CD4+CD25-T cells in SLE patients PBMCs,but the ratio of CD25-CD132+/CD4+ was lower and negatively correlated with the SLEDAI;The CD132 mRNA relative abundance in CD4+CD25-T cells was also lower than that in the control group;After CD4+CD25-T cells in peripheral blood of SLE patients were induced,the percentage of CD25+Foxp3+T cells in CD4+T cells was lower than that in the control group and negatively correlated with the SLEDAI;The ratio of CD25+CD122+/CD4+and CD25+CD132+/CD4+ in cells which were transformed from CD4+CD25-T cells in SLE patients was lower than that in the control group,but only the latter was negatively correlated with SLEDAI. The expression of phosphorylated Stat5 in transformed cells of SLE patients was lower than that in the control group and the ratio of pStat5+/CD25+CD4+ was negatively correlated with SLEDAI and positively correlated with the ratio of CD25+Foxp3+/CD4+. Conclusion:There was obviously defective expression of CD132 (IL-2Rγ chain) on CD4+CD25-T cells in peripheral blood of SLE patients and it was correlated with disease activity;The expression of CD132 and CD122 (IL-2Rβ chain) was also defective when the cells were transformed into CD4+CD25+T cell subsets,but only the defective expression of CD132 was correlated with disease activity and Foxp3 expression and was accompanied by lower levels of phosphorylated Stat5,suggesting that the defective expression of IL-2Rγ chain and its weaker downstream signal are closely related with SLE patients Foxp3+iTreg induction obstacle.