Objective:To investigate the risk factors of acute intracerebral hemorrhage (ICH) early prognosis and provide a theoretical basis for clinical treatment. Methods:A total of 666 patients with ICH were collected and followed up the clinical outcomes for 21 days. Monovariant and multivariant logistic regression were performed to analyze the relationship between indicators,major treatment options of patients on admission and early prognosis. Results:Logistic regression analysis found that onset to admission time <6 hours (P = 0.003),suffering from high blood pressure on admission (P = 0.024),high blood glucose (P = 0.030),pulmonary infection (P = 0.035) and fever (P = 0.003),diagnostic score classification of stroke (P < 0.001) and bleeding sites (P = 0.032) were the risk factors in poor prognosis of ICH;the therapeutic plan of the combination of tradition Chinese and western medicine was the protective factor for ICH. Conclusion:The predictor of early prognosis by integrating multiple risk factors associated with acute ICH was beneficial for the implementation of individual clinical decision to reduce patients＇ mortality and raise their quality of life.