血清氧化型低密度脂蛋白水平对颈动脉粥样硬化斑块稳定性的诊断价值
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省医学重点人才(K201110);江苏省自然科学基金(BK2011770)


The diagnostic value of serum oxLDL for carotid atherosclerotic plaque stability
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨血清氧化型低密度脂蛋白(oxLDL)水平对颈动脉粥样硬化斑块稳定性的诊断价值。方法:选取2013年10月至2014年4月在本院内科收治的住院患者中经颈动脉超声检查确诊为动脉粥样硬化斑块者130例,根据彩色多普勒超声检查结果分为动脉粥样硬化稳定斑块组-动脉粥样硬化不稳定斑块组;选取同期在本院体检中心行颈动脉超声检查的120例健康体检者作为对照组(无斑块者),同时检测受试者清晨血清总胆固醇(TC)-低密度脂蛋白胆固醇(LDL-C)及oxLDL水平。结果:3组间oxLDL水平的差异有统计学意义(F=213.11,P < 0.001)。经两两比较得出,不稳定斑块组高于稳定斑块组和正常组,稳定斑块组高于正常组。oxLDL所绘制ROC曲线下面积为0.808(P < 0.001)。结论:血清oxLDL水平对颈动脉粥样硬化斑块稳定性的诊断具有一定的临床价值。

    Abstract:

    Objective:This study was designed to investigate the diagnostic value of serum oxidized low density lipoprotein (oxLDL) for carotid atherosclerotic plaque stability. Methods:From Oct.2013 to Apr.2014,we enrolled 130 patients with carotid atherosclerotic plaque as the study group. All these patients were further divided into the unstable atherosclerotic plaque group and the stable atherosclerotic plaque group according to the results of color Doppler ultrasonography. Meanwhile,120 people receiving physical examination in medical examination room and diagnosed with no carotid atherosclerotic plaque were recruited as the control group. The levels of serum TC,LDL-C and oxLDL were examined in all 250 patients. Results:The difference of serum oxLDL level among three groups was statistically significant (F=213.11,P < 0.001). The level of serum oxLDL was much higher in the unstable atherosclerotic plaque group than that of the stable atherosclerotic plaque group,and was lowest in the control group. The area under ROC curve about oxLDL were 0.863 (P < 0.01). Conclusion:The level of serum oxLDL has the diagnostic value for the stability of carotid atherosclerotic plaque.

    参考文献
    相似文献
    引证文献
引用本文

朱 敖,吕 荣,沈 昊,杨鸿林,陆 洁,陆赵阳,周 蕾.血清氧化型低密度脂蛋白水平对颈动脉粥样硬化斑块稳定性的诊断价值[J].南京医科大学学报(自然科学版),2015,(10):1397-1400

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2015-02-19
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2015-10-28
  • 出版日期:
通知关闭
郑重声明