趋化因子CCL5在系统性红斑狼疮患者中的表达及临床意义
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国家自然科学基金(81302575);江苏省自然科学基金(BK20131028)


Expression of CCL5 in patients with systemic lupus erythematosus and its clinical significance
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    摘要:

    目的:检测系统性红斑狼疮(systemic lupus erythmatosus,SLE)患者血浆趋化因子CCL5表达,分析CCL5表达与SLE疾病活动性及脏器受累的关系。方法:收集31例SLE患者-16例健康志愿者外周血标本,SLE患者根据肾脏受累分为狼疮肾炎21例和SLE无肾脏受累10例。酶联免疫吸附法(ELISA)检测血浆CCL5水平,并分析其与SLE临床指标之间的关系。结果:SLE患者CCL5表达高于正常对照组;狼疮肾炎组患者CCL5表达高于SLE无肾脏受累组和正常对照组,差异具有统计学意义(P < 0.01);分析发现血浆CCL5表达水平与SLE疾病活动指数(SLEDAI)呈正相关(r=0.54)。结论:趋化因子CCL5在SLE发病机制中具有重要作用,可能参与了SLE肾脏受累过程;CCL5可作为判断SLE病情活动性的指标。

    Abstract:

    Objective:To investigate the level of CCL5 in patients with systemic lupus erythematosus (SLE), and to analyze the relationship between CCL5 expression, SLE disease activity and organ involvement. Methods: The plasma levels of CCL5 were measured by enzyme-linked immunosorbent assay (ELISA) in 31 SLE patients and 16 healthy people. Of the 31 SLE patients, according to renal involvement, there were 21 cases of lupus nephritis and 10 cases of SLE without renal involvement. CCL5 level was detected by enzyme-linked immunosorbent assay (ELISA), and its relationship with SLE clinical parameters was analyzed. Results: The expression of CCL5 was significantly increased in the SLE group compared with that of the normal controls. The expression level of CCL5 was significantly higher in the lupus nephritis group than that of the no kidney involvement group and the healthy control group. The expression level of CCL5 was positive correlated to SLE disease activity index (DAI) (r=0.54). Conclusion: Chemokine CCL5 may play a key role in the pathogenesis of SLE, including the renal involvement. CCL5 is also a serological marker of disease activity in patients with SLE.

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欧阳春,王艳艳.趋化因子CCL5在系统性红斑狼疮患者中的表达及临床意义[J].南京医科大学学报(自然科学版),2015,(10):1418-1420

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  • 收稿日期:2015-06-23
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  • 在线发布日期: 2015-10-28
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