YKL-40蛋白在小细胞肺癌组织中的表达及其临床意义
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Expression of YKL-40 in small cell lung cancer and its clinical significance
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    摘要:

    目的:探讨YKL-40蛋白的表达与小细胞肺癌(small cell lung cancer,SCLC)临床病理特征及预后的关系。方法:采用免疫组织化学Envision法检测105例SCLC组织和40例癌旁组织YKL-40蛋白的表达情况。结果:YKL-40 在SCLC组织和癌旁组织中的阳性率分别为72.4%和22.5%,差异有统计学意义(P < 0.01);YKL-40的表达与患者性别-年龄和吸烟情况无显著相关,而与临床分期-淋巴结转移有关,差异有统计学意义(P < 0.05)。105例SCLC患者的中位生存期(overall survival,OS)为16.3个月;YKL-40阳性表达者中位OS为12.4个月,明显短于阴性表达者的中位OS 25.6个月,两者差异有统计学意义(P < 0.05)。单因素分析显示,临床分期和YKL-40表达与预后相关;多因素分析显示YKL-40的表达可以作为SCLC的独立预后因素。结论:YKL-40蛋白可以作为一个预测SCLC患者术后复发-转移及预后的分子标记物。

    Abstract:

    Objective:To study the relationship between the expression of YKL-40 and clinicopathologic characteristics and prognosis in small cell lung cancer (SCLC). Methods:The expression of YKL-40 in 105 samples of SCLC tissues and 40 samples of para-cancerous tissues were examined by immunohistochemistry. Results:The expressions of YKL-40 in cancer tissues and para-cancerous tissues were 72.4% and 22.5%,respectively(both P < 0.01). The expression of YKL-40 was not associated with gender,age and smoking,but associated with clinical stage and lymph node metastasis (both P < 0.05). Median overall survival (OS)of SCLC patients was 16.3 months. Median OS in patients with YKL-40 expression was 12.4 months,which was shorter than that in patients without YKL-40 expression(25.6 months),and there was statistically differences (P < 0.05). Univariate analysis showed that clinical stage and the expression of YKL-40 were related to the prognosis of SCLC patients,while multivariate analysis showed that YKL-40 was an independent prognosis factor of SCLC patients. Conclusion:YKL-40 may be a molecular marker to predict the relapse,metastasis and prognosis of SCLC patients.

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胡慧娣,万明月,张元庆,徐春华. YKL-40蛋白在小细胞肺癌组织中的表达及其临床意义[J].南京医科大学学报(自然科学版),2015,(11):1538-1541

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  • 收稿日期:2015-08-13
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  • 在线发布日期: 2015-11-30
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