2012—2014年临床分离鲍曼不动杆菌分布情况及耐药性分析
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国家自然科学基金(81471994,81000754)


Clinical distribution and analysis of antimicrobial resistance among Acinetobacter baumannii isolated from 2012 to 2014 in Xuzhou
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    摘要:

    目的:了解徐州医学院附属医院2012—2014年鲍曼不动杆菌的标本来源-科室分布情况及3年间的耐药性变迁。方法:采用美国BD公司Phoenix 100全自动微生物分析系统进行菌株鉴定,采用纸片扩散(K-B)法测定菌株对抗菌药物的敏感性,以WHONET5.6软件分析数据。结果:2012—2014年分别分离鲍曼不动杆菌1 213-1 492-1 712株,各占非发酵革兰阴性杆菌的53.5%-44.4%和39.9%;其中标本来源以痰液为主,达89.2%;急诊ICU的感染率最高,达37.5%。除了左氧氟沙星-阿米卡星-多粘菌素和复方新诺明4种抗菌药物外,3年中鲍曼不动杆菌对头孢类-碳青霉烯类-喹诺酮类-氨基糖苷类等临床常用药耐药率均达80.0%以上。其中亚胺培南的耐药率从2012年的83.1%上升至2013年的87.1%,2014年下降至82.8%;与之类似,鲍曼不动杆菌对美洛培南的耐药率在2012-2013-2014年分别为84.9%-87.7%-85.1%;对多粘菌素的耐药率最低,为1.5%~2.9%。结论:与2012年相比,2013年鲍曼不动杆菌的耐药率明显升高,2014年有所下降,但仍非常严重,需高度警惕,加强鲍曼不动杆菌耐药监测和规范临床合理用药。

    Abstract:

    Objective:To investigate the specimen source,clinical distribution and antimicrobial resistance of Acinetobacter baumannii isolated from Affiliated Hospital of Xuzhou Medical College from 2012 to 2014. Methods:Acinetobacter baumannii isolates were identified by BD Phoenix 100 automatic microbial identification system (USA). The susceptibility testing was performed by Kirby-Bauer diffusion method,and the antimicrobial susceptibility data were analyzed by WHONET 5.6 software. Results:The isolated Acinetobacter baumannii of 2012-2014 strains were 1213,1492 and 1712,respectively,accounting for 53.5%,44.4% and 39.9% of the non-fermentative gram negative bacilli,respectively. The Acinetobacter baumannii strains were mainly isolated from sputum specimens (89.2%),and the Acinetobacter baumannii infection mainly distributed in emergency intensive care unit (ICU)(37.5%). Except for levofloxacin,amikacin,polymyxin and sulfamethoxazole compound,the resistance of Acinetobacter baumannii to cephalosporins,carbapenem,quinolones and aminoglycoside reached more than 80.0% in 3 years. The resistance rate of imipenem increased from 83.1% in 2012 to 87.1% in 2013,subsequently,the rate decreased to 82.8% by 2014. Likewise,the resistance rates of meropenem were 84.9%,87.7% and 85.1% from 2012 to 2014,respectively. Nevertheless,the resistance rate of polymyxin was the lowest,ranging from 1.5% to 2.9%. Conclusion:Antimicrobial resistance rate of Acinetobacter baumannii isolated from 2013 exhibited an apparent increasing compared to that from 2012,and then decreased in 2014,but still very serious,which should be paid more attention to. Therefore,monitoring of the resistant of Acinetobacter baumannii and the management of clinical rational use of antimicrobial drugs should be strengthened.

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秦婷婷,康海全,邓丽华,徐银海,顾 兵,马 萍.2012—2014年临床分离鲍曼不动杆菌分布情况及耐药性分析[J].南京医科大学学报(自然科学版),2015,(11):1615-1619

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  • 收稿日期:2015-06-01
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  • 在线发布日期: 2015-11-30
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