白色脂肪米色化及其在代谢平衡中的调控作用
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Beigeing fat development and its roles in the regulation of metabolic homeostasis
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    摘要:

    肥胖是由于机体能量摄取与消耗失衡而产生的体内脂肪堆积过多状态,现已成为全球范围迅速增加的一种流行疾病,严重威胁人们的健康-如何预防和治疗肥胖也成为备受关注的科学问题-最近研究发现,在冷刺激条件下,小鼠皮下白色脂肪组织中会出现棕色样脂肪细胞(米色脂肪细胞,beige adipocytes)-与以储存脂类物质为主要功能的白色脂肪细胞不同,米色脂肪细胞具有棕色脂肪相似的产热功能,可促进能量消耗-因此,米色脂肪细胞的发现为预防和治疗肥胖及其相关代谢性疾病提供了新的靶点-文章就脂肪米色化(beigeing of fat)的功能及其调控作一简要综述-

    Abstract:

    Obesity, which results from dysregulated energy homeostasis due to excessive energy intake and/or reduced energy expenditure, has now become a rapidly increasing worldwide epidemic that seriously threatens people's health. How to prevent and treat obesity has become a major research focus for basic and clinic scientists in the metabolic research field. Recent studies have identified a new type of cells in the subcutaneous white adipose tissue that develop thermogenic functions under the conditions of cold stimulation. These brown fat-like cells, or beige cells, are different from classic white adipocytes that play a major role in the storage of lipids. Like brown adipocytes, beige adipocytes have thermogenic functions and are able to promote energy expenditure, suggesting they are an exciting target for the prevention and treatment of obesity and related metabolic diseases. In the current review, we will briefly summarize current findings on the functions of beige fat and the mechanisms regulating the beigeing process of white adipose tissue.

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刘碧莲,刘 峰.白色脂肪米色化及其在代谢平衡中的调控作用[J].南京医科大学学报(自然科学版),2016,(1):8-11

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  • 收稿日期:2015-11-20
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  • 在线发布日期: 2016-01-30
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