毛细支气管炎患儿血清人软骨糖蛋白及潮气呼吸肺功能改变
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南京医科大学科技发展基金面上项目(2013NJMU175)


Study of serum YKL-40 and tidal lung function in infants with bronchiolitis
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    摘要:

    目的:通过测定毛细支气管炎患儿的血清人软骨糖蛋白以及潮气量-达峰时间比和达峰容积比,以探讨各指标在毛细支气管炎中的意义-方法:检测毛细支气管炎患儿85例(轻度组40例-重度组45例)-普通肺炎患儿44例-对照组47例患儿的血清人软骨糖蛋白浓度,测定毛细支气管炎组与普通肺炎组患儿潮气量-达峰时间比和达峰容积比,并进行统计学分析-结果:血清人软骨糖蛋白浓度毛细支气管炎组高于肺炎组及对照组(P < 0.05)-轻度毛细支气管炎组-重度毛细支气管炎组及普通肺炎组3组潮气量差异无统计学意义(F=0.90,P=0.408)-达峰时间比3组间比较有统计学意义(H=74.844,P < 0.001);重度毛细支气管炎组低于轻度毛细支气管炎组(χ2=8.78,P < 0.05),轻度毛细支气管炎组低于普通肺炎组(χ2=27.50,P < 0.05)-达峰容积比3组间比较有统计学意义 (H=76.392,P < 0.001);重度毛细支气管炎组低于轻度毛细支气管炎组(χ2=6.80,P < 0.05),轻度毛细支气管炎组低于普通肺炎组(χ2=32.70,P < 0.05)-相关性分析:达峰时间比与人软骨糖蛋白呈低度负相关(r =-0.278,P=0.001),达峰容积比与人软骨糖蛋白呈低度负相关(r =-0.272,P=0.002)-结论:人软骨糖蛋白可能参与毛细支气管炎的发病,婴儿潮气呼吸肺功能是评价毛细支气管炎患儿病情的客观指标-

    Abstract:

    Objective:To investigate the effect of YKL-40 and tidal lung function in infants with bronchiolitis by measuring the serumYKL-40, tidal volume, the level of time to peak tidal expiratory flow (TPTEF), ratio of TPTEF to total expiratory time (TPTEF/TE), volume to peak expiratory flow (VPEF), and ratio of VPEF to total expiratory volume (VPEF/VE). Methods: A total of 176 patients admitted to Wuxi Children's Hospital from September 2013 to May 2014 were enrolled. Eighty-five hospitalized infants with bronchiolitis (40 cases in the mild group and 45 cases in the severe group), 44 common pneumonia, and 47 normal children were enrolled in this study. The levels of serum YKL-40 and the tidal volume, TPTEF/TE, and VPEF/VE were determined by tidal breathing flow-volume loops and analyzed by statistical analysis. Results: YKL-40 was higher in the group of bronchiolitis compared to that in the pneumonia group and the control group (P < 0.05). There were no statistically significant differences in tidal volume (F=0.90, P=0.408). There was a significant difference of the ratio of TPTEF to TE (TPTEE/TE) in the three groups (H=74.844, P < 0.0001). The TPTEE/TE in the severe bronchiolitis group was lower than that in the mild bronchiolitis group (χ2=8.78, P < 0.05), which at the same time had the lower level than the pneumonia group (χ2=27.50, P < 0.05). In the three groups, the ratio of VPEF to VE (VPEF/VE) showed statistically different (H=76.392, P < 0.001). The VPEE/EE in the mild bronchiolitis group was statistically higher than that in the severe group (χ2=6.80, P < 0.05), which was lower than that in the pneumonia group (χ2=32.70, P < 0.05). YKL-40 was low negatively correlated with TPTEF/TE and VPEF/VE, (r=-0.278,P=0.001;r=-0.272,P=0.002), respectively. Conclusion: YKL-40 maybe an important inflammatory marker in bronchiolitis. The tidal lung function was a good monitoring and judgment index for bronchiolitis.

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张晓娟,项红霞,郁志伟,陈越新.毛细支气管炎患儿血清人软骨糖蛋白及潮气呼吸肺功能改变[J].南京医科大学学报(自然科学版),2016,(1):69-72

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  • 收稿日期:2015-05-27
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  • 在线发布日期: 2016-01-30
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