血清维生素D和甲状旁腺激素水平与心率收缩压乘积的关系
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国家自然科学基金青年基金项目(81102189);苏州市科技基金项目(SS0910)


The association between vitamin D,parathyroid hormone levels and the product of heart rate and systolic blood pressure in community-dwelling adults
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    摘要:

    目的:探讨一般人群血清维生素D和甲状旁腺激素与心率收缩压乘积的关系-方法:在前期横断面研究的基础上,抽取苏州市621名年龄≥40岁常住居民为研究对象-采用方差分析和广义线性模型分析不同25-羟基维生素D[25(OH)D]-甲状旁腺激素(PTH)水平分组下的心率-收缩压及心率收缩压乘积(RPP)的关系-结果:25(OH)D <10 μg/L组与≥20 μg/L组相比,心率增快(5.0 ± 1.2)次/min(P < 0.01),RPP增加(754.3 ± 187.8)次/min-mmHg(P < 0.01)-当PTH处于高水平时,25(OH)D<10 μg/L组与≥20 μg/L组相比,心率增快10.7次/min(P=0.001),RPP增加1 279.4 次/min-mmHg(P=0.011);调整多个因素后,心率仍增快8.2次/min(P=0.017),RPP增加1 041.8次/min-mmHg(P=0.06)-当PTH处于低水平时,25(OH)D<10 μg/L组与≥20 μg/L组相比,心率增快3.7次/min(P=0.018),RPP增加639.5次/min-mmHg(P=0.007);调整多因素后RPP仍增加595.7次/min-mmHg(P=0.012)-结论:维生素D缺乏者心率加快-RPP增加-心脏做功增加,尤其维生素D缺乏与高水平的PTH同时存在时对以上效应可能起到协同作用-

    Abstract:

    Objective:To investigate the relationship between the serum vitamin D,parathyroid hormone and the heart rate-systolic blood pressure product (RPP)among adults. Methods:Based on the previous cross-sectional study,data analyses were carried out on 621 permanent residents aged≥40 years old. Analysis of variance and generalized liner model analysis were used to analyze the relationship between the 25 (OH)D,PTH and heart rate,systolic blood pressure,RPP. Results:Compared to participants with 25(OH)D≥20 μg/L,those with 25(OH)D<10 μg/L had higher heart rate and RPP,by increasing (5.0 ± 1.2) beats/min (P < 0.01)and(754.3 ± 187.8) beats/min-mmHg (P < 0.01),respectively. Among the high PTH group,heart rate increased 10.7 beats/min(P=0.001)and RPP increased 1 279.4 beats/min-mmHg(P=0.011)in participants with 25(OH)D<10 μg/L compared to those with 25(OH)D≥20 μg/L. After adjustment for age,gender and other variables,heart rate and RPP also increased 8.2 beats/min(P=0.017)and 1 041.8 beats/min-mmHg (P=0.06)in those with 25 (OH)D<10 μg/L. While in the low PTH group,heart rate and RPP increased 3.7 beats/min (P=0.018)and 639.5 beats/min-mmHg (P=0.007)respectively,and the adjusted RPP increased 595.7 beats/min-mmHg(P=0.012)in participants with 25(OH)D<10 μg/L compared to those with 25(OH)D≥20 μg/L. Conclusion:Vitamin D deficiency is associated with the increase of heart rate and RPP, which suggestes low vitamin D status may increase cardiac work,especially combination of vitamin D deficiency and elevated PTH maybe play a co-effect on the cardiac work.

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许 倩,彭 浩,张 秋,马庆华,李红美.血清维生素D和甲状旁腺激素水平与心率收缩压乘积的关系[J].南京医科大学学报(自然科学版),2016,(2):234-238

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  • 收稿日期:2015-03-23
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  • 在线发布日期: 2016-02-29
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