Abstract:Objective:To evaluate the 3D T2 spectral adiabatic inversion recovery (SPAIR) Sampling Perfection with Application optimized Contrasts using different flip angle Evolutions(SPACE) sequence of elbow nerves in asymptomatic subjects by magnetic resonance neurography (MRN),and evaluate differences between different groups. Methods:MRN imaging was performed at 3.0 T MR. All 64 subjects underwent elbow nerve MRN covering the elbow region,including T2-weighted imaging with fat suppression and the isotropic 3D T2 SPAIR SPACE. For each volunteer,thin maximum intensity projection (MIP) and curved planar reconstruction (CPR) of coronal and sagittal position through the elbow nerves from proximal to distal were obtained from the same 3D dataset. Signal intensity (SI) and MRN images of elbow nerves were evaluated at three parts:upper arm,elbow joint and forearm. The increased SI of the three nerves on FS-T2WI and 3D T2 SPACE sequences were statistically compared to the surrounding muscle signals. Results:Images of high quality for all 64 volunteers were obtained by CPR. The neurography ratios of ulnar nerve by MIP from proximal to distal location were 92%,83% and 98%,and neurography ratios of median nerve and radial nerve were 81%,89% and 80%,as well as 94% and 95%,respectively. The increased SI of ulnar nerve on 2D FS-T2WI and 3D T2 SPACE sequences were 55% and 30%,respectively. Conclusion:The 3D T2 SPAIR SPACE sequence essentially improves the MRN of elbow nerves. SI abnormality of the ulnar nerve is more reliable on 3D SPAIR SPACE sequence.